ACTA1 and HIP1R

Number of citations of the paper that reports this interaction (PMID 11889126)
22

Data Source:
HPRD (in vitro)

		ACTA1	HIP1R
Gene Name		actin, alpha 1, skeletal muscle	huntingtin interacting protein 1 related
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytoskeleton Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Actin Binding Protein Binding Protein Binding, Bridging Phosphatidylinositol Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Receptor-mediated Endocytosis Actin Cytoskeleton Organization
Pathways		Striated Muscle Contraction	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Parkinson's disease ( 21292315)
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	8 interactors: ACTA1 CLTA CLTB CLTC CTTN DYNLL1 HIP1 HTT
Entrez ID		58	9026
HPRD ID		00030	10412
Ensembl ID		ENSG00000143632	ENSG00000130787
Uniprot IDs		P68133 Q5T8M7	B3KN98 B3KQW8 O75146 Q6NXG8
PDB IDs		1T44	1R0D
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cytoskeleton Organization Actin Cytoskeleton Organization Cellular Protein Localization Actin Filament-based Process Protein Transport Endocytosis Establishment Of Protein Localization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Golgi Vesicle Transport Antigen Processing And Presentation Membrane Organization Transport Organelle Organization Protein Localization Establishment Of Localization In Cell Cell Differentiation Developmental Process Neural Plate Formation Post-Golgi Vesicle-mediated Transport Cellular Localization Anatomical Structure Morphogenesis Serotonin Uptake Skeletal Muscle Fiber Adaptation Lactate Biosynthetic Process From Pyruvate Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Phosphatase Type 2A Activity Regulation Of Cell Death Mitotic Cell Cycle Process Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Transport Mitotic Cell Cycle Lactate Biosynthetic Process Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Cellular Component Assembly Quinolinate Metabolic Process
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Intersection) ?