ACTA1 and TNNI3K

Number of citations of the paper that reports this interaction (PMID 12721663)
9

Data Source:
HPRD (two hybrid)

		ACTA1	TNNI3K
Gene Name		actin, alpha 1, skeletal muscle	TNNI3 interacting kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Protein Phosphorylation
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			Body mass index ( 23669352 20935630) Obesity ( 23563607) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	7 interactors: ACTA1 ACTC1 AIP FABP3 HADHB MYBPC3 TNNI3
Entrez ID		58	51086
HPRD ID		00030	18208
Ensembl ID		ENSG00000143632	ENSG00000116783
Uniprot IDs		P68133 Q5T8M7	Q59H18
PDB IDs		1T44
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Muscle System Process Muscle Tissue Morphogenesis Muscle Organ Development Heart Contraction Muscle Organ Morphogenesis Striated Muscle Tissue Development Myofibril Assembly Skeletal Muscle Thin Filament Assembly Muscle Tissue Development Striated Muscle Contraction Skeletal Myofibril Assembly Actomyosin Structure Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Actin Filament-based Process Heart Morphogenesis Striated Muscle Cell Differentiation Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Blood Circulation Muscle Cell Differentiation Ventricular Cardiac Muscle Tissue Development Cardiac Ventricle Morphogenesis Organelle Assembly Heart Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Skeletal Muscle Fiber Adaptation Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Tissue Morphogenesis Cardiac Chamber Development Tissue Development Regulation Of Muscle Contraction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Muscle Filament Sliding Myosin Filament Assembly Cardiovascular System Development Positive Regulation Of Phospholipid Biosynthetic Process Cardiolipin Acyl-chain Remodeling Long-chain Fatty Acid Import
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?