ACTA1 and DNASE1

Number of citations of the paper that reports this interaction (PubMedID 11707283)
0

Data Source:
HPRD (in vitro, in vivo)

		ACTA1	DNASE1
Description		actin alpha 1, skeletal muscle	deoxyribonuclease 1
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GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Extracellular Region Nucleus Nuclear Envelope Cytoplasmic Vesicle Zymogen Granule Extracellular Exosome
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	DNA Binding Actin Binding Catalytic Activity Nuclease Activity Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Catabolic Process Apoptotic Process Regulation Of Neutrophil Mediated Cytotoxicity
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Body mass index ( 29273807) Monocyte percentage of white cells ( 32888494)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	4 interacting genes: ACTA1 ACTA2 ACTB ACTG1
Entrez ID		58	1773
HPRD ID		00030	00509
Ensembl ID		ENSG00000143632	ENSG00000213918
Uniprot IDs		P68133	P24855
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	4AWN
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Actin Cytoskeleton Mesenchyme Migration Regulation Of Transepithelial Transport Dense Body Actin Filament Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Lamellipodium Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Positive Regulation Of Macromolecule Biosynthetic Process Platelet Aggregation Positive Regulation Of Biosynthetic Process Homotypic Cell-cell Adhesion Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Filopodium Cytoskeleton Cell Body Extracellular Space Stress Fiber Positive Regulation Of Hepatic Stellate Cell Contraction Protein Localization To Cell Junction Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Metabolic Process Schaffer Collateral - CA1 Synapse Hydrolase Activity Nucleotide Binding Cell-cell Junction Assembly Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Norepinephrine Uptake Axonogenesis Juxtaglomerular Apparatus Development Transporter Regulator Activity Extracellular Exosome Cell-cell Junction Organization Glomerular Mesangial Cell Development Smooth Muscle Contractile Fiber
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