ACTA1 and DNASE1

Number of citations of the paper that reports this interaction (PMID 2395459)
347

Data Source:
HPRD (in vivo, in vitro)

		ACTA1	DNASE1
Gene Name		actin, alpha 1, skeletal muscle	deoxyribonuclease I
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Nucleus Nuclear Envelope Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Actin Binding Endodeoxyribonuclease Activity Deoxyribonuclease I Activity Protein Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	DNA Catabolic Process, Endonucleolytic Apoptotic Process
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	4 interactors: ACTA1 ACTA2 ACTB ACTG1
Entrez ID		58	1773
HPRD ID		00030	00509
Ensembl ID		ENSG00000143632
Uniprot IDs		P68133 Q5T8M7	P24855
PDB IDs		1T44	4AWN
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Platelet Aggregation Cell Development Response To External Stimulus Retina Homeostasis Myofibril Assembly Adherens Junction Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Striated Muscle Cell Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Muscle Cell Development Skeletal Muscle Fiber Adaptation Tissue Homeostasis Platelet Activation Cell Junction Assembly Cell Differentiation Cell-cell Junction Organization Muscle Contraction Striated Muscle Cell Differentiation Multicellular Organismal Homeostasis Muscle System Process Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Glomerular Mesangial Cell Development Movement Of Cell Or Subcellular Component System Development Mesangial Cell Development Skeletal Muscle Thin Filament Assembly Muscle Cell Differentiation Homotypic Cell-cell Adhesion Renal Interstitial Fibroblast Development Skeletal Myofibril Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Skeletal Muscle Adaptation Axon Guidance Multicellular Organismal Development Blood Coagulation Anatomical Structure Development Hemostasis Cellular Component Assembly Vascular Smooth Muscle Contraction Immune Response-regulating Signaling Pathway Organelle Assembly Muscle Structure Development Single Organismal Cell-cell Adhesion Axonogenesis
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	chip crx dhs distinguish epigenetic essentially genome great h3k27me3 h3k4me2 hypersensitive identifying maps merged novo photoreceptor pol probability reflective retina retinal rod seq sets signature signatures striking unbiased widespread
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	chip crx dhs distinguish epigenetic essentially genome great h3k27me3 h3k4me2 hypersensitive identifying maps merged novo photoreceptor pol probability reflective retina retinal rod seq sets signature signatures striking unbiased widespread
Tagcloud (Intersection) ?