HTRA2 and PDXDC1

Number of citations of the paper that reports this interaction (PMID 17266347)
23

Data Source:
BioGRID (unspecified method)

		HTRA2	PDXDC1
Gene Name		HtrA serine peptidase 2	pyridoxal-dependent decarboxylase domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex	Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding	Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Carboxylic Acid Metabolic Process
Pathways
Drugs
Diseases
GWAS			Height ( 20189936) Metabolic traits ( 21886157) Phospholipid levels (plasma) ( 21829377 22359512)
Protein-Protein Interactions		37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP	2 interactors: BCAP29 HTRA2
Entrez ID		27429	23042
HPRD ID		05919	13789
Ensembl ID		ENSG00000115317	ENSG00000179889
Uniprot IDs		O43464	H3BND4 J3KNK7 Q6P996
PDB IDs		1LCY 2PZD
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway	Pentacyclic Triterpenoid Metabolic Process Protein Localization To Endoplasmic Reticulum Exit Site Response To Herbicide Protein Autoprocessing Regulation Of Mitochondrion Degradation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cellular Response To Interferon-beta Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Interferon-beta Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Adult Walking Behavior Regulation Of Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Retinoic Acid Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Ceramide Metabolic Process ER To Golgi Vesicle-mediated Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Autophagy Response To Heat Adult Locomotory Behavior Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Localization To Endoplasmic Reticulum Isoprenoid Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Retinoic Acid Positive Regulation Of Endopeptidase Activity Osteoblast Differentiation Positive Regulation Of Peptidase Activity
Tagcloud ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?