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ACTA1 and PARVA
Number of citations of the paper that reports this interaction (PubMedID
11171322
)
0
Data Source:
HPRD
(in vitro)
ACTA1
PARVA
Description
actin alpha 1, skeletal muscle
parvin alpha
Image
GO Annotations
Cellular Component
Stress Fiber
Extracellular Space
Cytoplasm
Cytosol
Cytoskeleton
Striated Muscle Thin Filament
Actin Filament
Actin Cytoskeleton
Sarcomere
Lamellipodium
Filopodium
Cell Body
Extracellular Exosome
Blood Microparticle
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Anchoring Junction
Molecular Function
Nucleotide Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Hydrolase Activity
Myosin Binding
ADP Binding
Actin Binding
Protein Kinase Inhibitor Activity
Protein Binding
Cadherin Binding
Biological Process
Muscle Contraction
Positive Regulation Of Gene Expression
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Fiber Development
Mesenchyme Migration
Angiogenesis
Sprouting Angiogenesis
Outflow Tract Septum Morphogenesis
Chemotaxis
Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cell Shape
Cell Projection Organization
Actin Cytoskeleton Organization
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Protein Stabilization
Cilium Assembly
Actin-mediated Cell Contraction
Smooth Muscle Cell Chemotaxis
Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape
Plasma Membrane Bounded Cell Projection Assembly
Pathways
Striated Muscle Contraction
Regulation of CDH1 Function
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the dystrophin-glycoprotein complex (DGC)
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Latrunculin A
Sucrose
Ulapualide A
Kabiramide C
Jaspisamide A
Tmr
1-Methylhistidine
Phosphoaminophosphonic Acid-Adenylate Ester
Aplyronine A
Reidispongiolide A
Reidispongiolide C
Sphinxolide B
Latrunculin B
Diseases
Cap myopathy
Congenital fiber type disproportion (CFTD)
Nemaline myopathy
GWAS
Depressive symptoms (SSRI exposure interaction) (
25649181
)
Diisocyanate-induced asthma (
25918132
)
Epstein-Barr virus copy number in lymphoblastoid cell lines (
28654678
)
HOMA-B (corrected for HOMA-IR) (
30369944
)
Lung adenocarcinoma (
28604730
)
Mortality in heart failure (
20400778
)
Rheumatic heart disease (
34106200
)
Interacting Genes
115 interacting genes:
ABL1
ABRA
ACTR10
ACTR1B
ADSS2
AFAP1
AIF1
AJUBA
AMOT
ANXA2
BIN1
CCIN
CCT2
CCT4
CCT5
CFL1
CLIC5
CNN1
CORO2B
COTL1
CTNND1
CTTN
CYFIP1
CYTH1
DHX9
DLG1
DMD
DNASE1
DNMBP
DTNA
DUX4L9
EGFR
EPB41
EPB41L2
EPS8
FGD4
FHOD1
FSCN1
GAS2
GAS7
GC
GSN
HCLS1
HDAC4
HIP1R
HSPB2
HTRA2
IQGAP1
ITGA2
ITPKA
KIF23
KLHL20
LASP1
LINC00624
MACF1
MAP1A
MAPT
MIB2
MINPP1
MYL1
MYLK
MYO10
MYO6
MYO7A
MYO9B
NEXN
NR3C2
NRAP
PAK1
PARVA
PCYT1B
PFDN1
PFN1
PHACTR1
PLD1
PPP1R9B
PRKCA
PRKCD
PRKCE
RAC1
RNF167
RPS6KB1
S100A1
S100A4
SCIN
SMTN
SNCA
SORBS1
SPRR1A
SPTA1
SPTAN1
SPTBN2
TAGLN
TJP1
TLN1
TMSB4X
TMSB4Y
TNNI1
TNNI3
TNNI3K
TP53
TPM2
TPM3
TRIM55
TRIM63
TTN
UBC
USP25
USP6NL
UTRN
VASP
VAV1
VCL
VIL1
XIRP1
15 interacting genes:
ACTA1
APP
FERMT1
FERMT2
FERMT3
HSPB2
ILK
LIMS1
MAP2K1
MLH1
NFE2L1
OGT
PXN
UBE3A
UBQLN1
Entrez ID
58
55742
HPRD ID
00030
16283
Ensembl ID
ENSG00000143632
ENSG00000197702
Uniprot IDs
P68133
Q9NVD7
PDB IDs
7RNS
7RNU
7RNV
9DUU
9DUV
2K2R
2VZC
2VZD
2VZG
2VZI
3KMU
3KMW
3REP
6MIB
Enriched GO Terms of Interacting Partners
?
Actin Binding
Actin Filament Binding
Cytoskeleton
Actin Cytoskeleton
Actin Filament-based Process
Cytoplasm
Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament Organization
Actin Cytoskeleton Organization
Supramolecular Fiber Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Filament Length
Regulation Of Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Cytosol
Regulation Of Cellular Component Size
Regulation Of Protein-containing Complex Assembly
Cell Cortex
Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Organelle Organization
Positive Regulation Of Cytoskeleton Organization
Negative Regulation Of Supramolecular Fiber Organization
Lamellipodium
Ruffle
Actin Filament
Negative Regulation Of Cytoskeleton Organization
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Protein Localization
Cortical Actin Cytoskeleton
Positive Regulation Of Cellular Component Biogenesis
Actin Polymerization Or Depolymerization
Regulation Of Biological Quality
Anchoring Junction
Organelle Organization
Ruffle Membrane
Positive Regulation Of Protein-containing Complex Assembly
Cell Projection
Filopodium
Regulation Of Cell Shape
Muscle System Process
Negative Regulation Of Actin Filament Depolymerization
Regulation Of Protein Localization
Integrin Binding
Substrate Adhesion-dependent Cell Spreading
Cell-substrate Adhesion
Anchoring Junction
Focal Adhesion
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Positive Regulation Of Cell-substrate Adhesion
Cell Adhesion
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Proteolysis
Cell Cortex
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Cell-matrix Adhesion
Positive Regulation Of Biosynthetic Process
Glial Cell Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of ATP Metabolic Process
Regulation Of Cell-substrate Adhesion
Integrin Activation
Positive Regulation Of Integrin Activation
Positive Regulation Of Gene Expression
Cytosol
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of Cell Adhesion
Stress Fiber
Chemical Homeostasis
Positive Regulation Of Cell Communication
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Regulation Of Response To Endoplasmic Reticulum Stress
Cell Development
Regulation Of Cell Junction Assembly
Regulation Of Protein Localization
Regulation Of Integrin Activation
Positive Regulation Of Cell Migration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Positive Regulation Of Cell Motility
Schwann Cell Development
Regulation Of Cell Migration
Positive Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Small Molecule Metabolic Process
Protein Serine/threonine Kinase Binding
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