HTRA2 and HSD17B10

Number of citations of the paper that reports this interaction (PMID 17266347)
23

Data Source:
BioGRID (enzymatic study)

		HTRA2	HSD17B10
Gene Name		HtrA serine peptidase 2	hydroxysteroid (17-beta) dehydrogenase 10
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Poly(A) RNA Binding 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Lipid Metabolic Process TRNA Processing Branched-chain Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Branched-chain amino acid catabolism Metabolism of amino acids and derivatives
Drugs			NADH Nicotinamide-Adenine-Dinucleotide 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP	5 interactors: APP CHD3 FAF1 HTRA2 UBE2D1
Entrez ID		27429	3028
HPRD ID		05919	02223
Ensembl ID		ENSG00000115317	ENSG00000072506
Uniprot IDs		O43464	Q99714
PDB IDs		1LCY 2PZD	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway	Positive Regulation Of Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Multicellular Organism Growth Pentacyclic Triterpenoid Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Cellular Macromolecule Catabolic Process Regulation Of Catalytic Activity Adult Behavior Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Locomotory Behavior Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Regulation Of Developmental Growth Neuron Remodeling Response To Herbicide Protein Autoprocessing Regulation Of Mitochondrion Degradation Negative Regulation Of Proteolysis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Peptidase Activity
Tagcloud ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	10c 17beta abad abnormally abound allopregnanolone alternate avenue belief catalyzes dehydrogenase homotetrameric hydroxysteroid infantile isoleucine misconceptions misnomer missense mistaken multifunctional negligible neuroactive opened predicated properly psychomotor steroids xp11
Tagcloud (Difference) ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	10c 17beta abad abnormally abound allopregnanolone alternate avenue belief catalyzes dehydrogenase homotetrameric hydroxysteroid infantile isoleucine misconceptions misnomer missense mistaken multifunctional negligible neuroactive opened predicated properly psychomotor steroids xp11
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