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ORC4 and HIST4H4
Number of citations of the paper that reports this interaction (PMID
20850016
)
133
Data Source:
BioGRID
(unspecified method)
ORC4
HIST4H4
Gene Name
origin recognition complex, subunit 4
histone cluster 4, H4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Nucleolus
Cytoplasm
Actin Cytoskeleton
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
Nucleotide Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Pubertal anthropometrics (
23449627
)
Protein-Protein Interactions
27 interactors:
APP
CCND1
CDKN2A
CTBP1
FBXL5
FBXL8
FBXO25
FBXO6
HIST3H3
HIST4H4
KPNA1
MCM10
MCM2
MCM3
MCM4
MCM6
MCM7
MLH1
MTUS1
ORC1
ORC2
ORC3
ORC5
ORC6
RPA2
RRM2B
TCF4
52 interactors:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING1
ING2
KAT2A
KAT2B
KAT6A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT6
RAG1
RPS6KA5
SAP30
SET
SETD8
SETDB1
SIAH1
SMARCA5
TAF1A
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
Entrez ID
5000
121504
HPRD ID
09118
13662
Ensembl ID
ENSG00000115947
ENSG00000197837
Uniprot IDs
A8K7H4
O43929
Q96B14
B2R4R0
P62805
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
Enriched GO Terms of Interacting Partners
?
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Metabolic Process
DNA-dependent DNA Replication
DNA Replication
DNA Replication Initiation
Cell Cycle Process
Cell Cycle
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Nitrogen Compound Metabolic Process
Chromosome Organization
DNA Unwinding Involved In DNA Replication
Cellular Macromolecule Biosynthetic Process
Cellular Metabolic Process
Macromolecule Biosynthetic Process
DNA Conformation Change
DNA Duplex Unwinding
DNA Geometric Change
Biosynthetic Process
Organelle Organization
Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Stress
Regulation Of Cell Cycle G2/M Phase Transition
Protein-DNA Complex Assembly
Cellular Response To DNA Damage Stimulus
Regulation Of DNA Recombination
Telomere Maintenance
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Proliferation
Regulation Of Cell Cycle Phase Transition
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Fat Cell Differentiation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of Cell Cycle
Chromatin Assembly
Cellular Process
Cellular Macromolecular Complex Assembly
Response To Epidermal Growth Factor
Regulation Of Protein Export From Nucleus
Chromatin Assembly Or Disassembly
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Peptidyl-lysine Modification
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Organelle Organization
Macromolecule Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Peptidyl-amino Acid Modification
Gene Expression
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Protein Acetylation
Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Protein Modification Process
Chromatin Assembly Or Disassembly
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Assembly
Positive Regulation Of Transcription, DNA-templated
Histone H3-K9 Modification
Histone Methylation
Positive Regulation Of Gene Expression
Cell Cycle
Nucleosome Assembly
DNA Packaging
Tagcloud
?
archaeon
cctb
chec2
dpsa
elfa
fumc
gapb
halobacterium
halophilic
imd2
ipg
msra
nrc
ppia
rphs6
rpl18e
rpl31eand
rps27ae
shsp
thic
thid
tpia
trh5
uvrc
vng0683c
vng1300h
vng1807h
vng6254
yufn
Tagcloud (Difference)
?
archaeon
cctb
chec2
dpsa
elfa
fumc
gapb
halobacterium
halophilic
imd2
ipg
msra
nrc
ppia
rphs6
rpl18e
rpl31eand
rps27ae
shsp
thic
thid
tpia
trh5
uvrc
vng0683c
vng1300h
vng1807h
vng6254
yufn
Tagcloud (Intersection)
?