ORC4 and RDH5

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		ORC4	RDH5
Description		origin recognition complex subunit 4	retinol dehydrogenase 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body
	Molecular Function	Nucleotide Binding DNA Binding DNA Replication Origin Binding Protein Binding ATP Binding	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity
	Biological Process	DNA Replication DNA Replication Initiation Polar Body Extrusion After Meiotic Divisions Protein Polymerization	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function
Drugs			NADH Vitamin A
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome	Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Estimated glomerular filtration rate ( 30604766 31015462 31152163) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4C16 KLHL20 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RRM2B TCF4	3 interacting genes: ORC4 RGR RLBP1
Entrez ID		5000	5959
HPRD ID		09118	03370
Ensembl ID		ENSG00000115947	ENSG00000135437
Uniprot IDs		A8K7H4 O43929 Q96B14	Q92781
PDB IDs		5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Origin Recognition Complex DNA Replication Origin Binding DNA Metabolic Process CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Single-stranded DNA Binding Regulation Of DNA Replication Nucleus Mitotic DNA Replication Initiation Single-stranded DNA Helicase Activity Regulation Of DNA Metabolic Process Chromosome Nucleic Acid Metabolic Process DNA Damage Response DNA Helicase Activity Nucleoplasm DNA Repair DNA Binding Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Recombination Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Recombinational Repair DNA Strand Elongation Cellular Response To Stress DNA-templated DNA Replication SCF Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Mammary Gland Epithelial Cell Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Enzyme Binding Nucleolus Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Cell Population Proliferation Regulation Of Cell Cycle G2/M Phase Transition Amyloid Fibril Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin
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