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ORC4 and RRM2B
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
ORC4
RRM2B
Description
origin recognition complex subunit 4
ribonucleotide reductase regulatory TP53 inducible subunit M2B
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Nucleolus
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Ribonucleoside-diphosphate Reductase Complex
Molecular Function
Nucleotide Binding
DNA Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor
Protein Binding
Oxidoreductase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
DNA Replication
DNA Replication Initiation
Polar Body Extrusion After Meiotic Divisions
Protein Polymerization
DNA Synthesis Involved In DNA Repair
Kidney Development
Renal System Process
Mitochondrial DNA Replication
DNA Repair
DNA Damage Response
Response To Oxidative Stress
Ribonucleoside Diphosphate Metabolic Process
Deoxyribonucleoside Triphosphate Metabolic Process
Deoxyribonucleotide Biosynthetic Process
2'-deoxyribonucleotide Biosynthetic Process
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Response To Amine
Positive Regulation Of G0 To G1 Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Drugs
Cladribine
Diseases
Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
Mitochondrial DNA depletion syndrome (MDS)
GWAS
Estimated glomerular filtration rate (
30604766
31015462
31152163
)
Loneliness (MTAG) (
29970889
)
Serum uric acid levels (
30993211
)
Urate levels (
31578528
)
Blood protein levels (
30072576
)
Chromosomal aberration frequency (total) (
31586183
)
Chronic obstructive pulmonary disease (
28166215
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular volume (
29403010
)
Red blood cell count (
32888494
)
Interacting Genes
28 interacting genes:
APP
CCND1
CDKN2A
CTBP1
FBXL5
FBXL8
FBXO25
FBXO6
H3-4
H4C16
KLHL20
KPNA1
MCM10
MCM2
MCM3
MCM4
MCM6
MCM7
MLH1
MTUS1
ORC1
ORC2
ORC3
ORC5
ORC6
RDH5
RRM2B
TCF4
9 interacting genes:
CDKN1A
CSNK2A1
MDM2
ORC4
RNF41
RRM1
RRM2
SRPK2
TP53
Entrez ID
5000
50484
HPRD ID
09118
05276
Ensembl ID
ENSG00000115947
ENSG00000048392
Uniprot IDs
A8K7H4
O43929
Q96B14
Q7LG56
PDB IDs
5UJ7
5UJM
7CTE
7CTF
7CTG
7JPO
7JPP
7JPQ
7JPR
7JPS
8RWV
8S0C
8S0D
8S0E
8S0F
2VUX
3HF1
4DJN
Enriched GO Terms of Interacting Partners
?
DNA Replication Initiation
DNA Replication
Nuclear Origin Of Replication Recognition Complex
Chromosome, Telomeric Region
Origin Recognition Complex
DNA Replication Origin Binding
DNA Metabolic Process
CMG Complex
MCM Complex
Double-strand Break Repair Via Break-induced Replication
Regulation Of DNA-templated DNA Replication Initiation
Single-stranded DNA Binding
Regulation Of DNA Replication
Nucleus
Mitotic DNA Replication Initiation
Single-stranded DNA Helicase Activity
Regulation Of DNA Metabolic Process
Chromosome
Nucleic Acid Metabolic Process
DNA Damage Response
DNA Helicase Activity
Nucleoplasm
DNA Repair
DNA Binding
Double-strand Break Repair
DNA Strand Elongation Involved In DNA Replication
ATP Hydrolysis Activity
Nucleobase-containing Compound Metabolic Process
Helicase Activity
DNA Recombination
Double-strand Break Repair Via Homologous Recombination
Macromolecule Metabolic Process
Recombinational Repair
DNA Strand Elongation
Cellular Response To Stress
DNA-templated DNA Replication
SCF Ubiquitin Ligase Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein-DNA Complex Assembly
Mammary Gland Epithelial Cell Proliferation
Regulation Of Mammary Gland Epithelial Cell Proliferation
Enzyme Binding
Nucleolus
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Nucleosome Assembly
Cell Population Proliferation
Regulation Of Cell Cycle G2/M Phase Transition
Amyloid Fibril Formation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To Gamma Radiation
Disordered Domain Specific Binding
Regulation Of Cell Cycle Process
Response To Ionizing Radiation
Signal Transduction In Response To DNA Damage
Cellular Response To Actinomycin D
Ribonucleoside-diphosphate Reductase Complex
Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor
Response To Actinomycin D
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Response To Gamma Radiation
Regulation Of Mitotic Cell Cycle
Cellular Response To UV-C
Positive Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Stress-induced Premature Senescence
Cellular Response To Ionizing Radiation
Cellular Response To UV
Cellular Response To Antibiotic
Protein-containing Complex Assembly
Protein Tetramerization
Signal Transduction By P53 Class Mediator
DNA Damage Checkpoint Signaling
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Negative Regulation Of Mitophagy
Cellular Response To Light Stimulus
Protein-containing Complex Organization
DNA Damage Response
Response To UV-C
Replicative Senescence
Positive Regulation Of Cell Cycle Phase Transition
2'-deoxyribonucleotide Biosynthetic Process
Deoxyribonucleotide Biosynthetic Process
Protein Heterotetramerization
Mitotic G1 DNA Damage Checkpoint Signaling
Regulation Of Cell Cycle G2/M Phase Transition
Cytosol
Regulation Of Signal Transduction By P53 Class Mediator
Cellular Component Assembly
Mitotic G1/S Transition Checkpoint Signaling
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of DNA Metabolic Process
Regulation Of Reactive Oxygen Species Metabolic Process
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