ORC4 and FBXL5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ORC4	FBXL5
Gene Name		origin recognition complex, subunit 4	F-box and leucine-rich repeat protein 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Actin Cytoskeleton	Ubiquitin Ligase Complex SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation	Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex	Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 HIST3H3 HIST4H4 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RPA2 RRM2B TCF4	8 interactors: CSNK2B DCTN1 EP300 NABP2 ORC4 PLK1 SKP1 SNAI1
Entrez ID		5000	26234
HPRD ID		09118	05739
Ensembl ID		ENSG00000115947	ENSG00000118564
Uniprot IDs		A8K7H4 O43929 Q96B14	Q9UKA1
PDB IDs			3U9J 3U9M 3V5X 3V5Y 3V5Z
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication DNA Replication DNA Replication Initiation Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process Chromosome Organization DNA Unwinding Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process DNA Conformation Change DNA Duplex Unwinding DNA Geometric Change Biosynthetic Process Organelle Organization Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Regulation Of DNA Recombination Telomere Maintenance Regulation Of Mitotic Cell Cycle Phase Transition Cell Proliferation Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Cell Cycle Chromatin Assembly Cellular Process Cellular Macromolecular Complex Assembly Response To Epidermal Growth Factor Regulation Of Protein Export From Nucleus Chromatin Assembly Or Disassembly	Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Notch Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone H2B Acetylation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Metabolic Process Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Activation Of APC-Cdc20 Complex Activity Positive Regulation Of Transferase Activity Cellular Response To Stimulus Response To Unfolded Protein Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Stress N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Binding Positive Regulation Of Cellular Protein Catabolic Process Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Response To Endoplasmic Reticulum Stress Mitotic Cell Cycle Checkpoint Polar Body Extrusion After Meiotic Divisions Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Protein Phosphorylation Circadian Rhythm Regulation Of Protein Kinase Activity
Tagcloud ?		archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn	cacybp carrying concept demethylase disability dosage encoding epigenetic functionally homologue insights intellectual interdependent kdm5c kdm5d lysine males marks methylation neurodevelopment neurodevelopmental normally occurring parallel promoters scmh1 sex shed top
Tagcloud (Difference) ?		archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn	cacybp carrying concept demethylase disability dosage encoding epigenetic functionally homologue insights intellectual interdependent kdm5c kdm5d lysine males marks methylation neurodevelopment neurodevelopmental normally occurring parallel promoters scmh1 sex shed top
Tagcloud (Intersection) ?