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APLF and FBXO25
Number of citations of the paper that reports this interaction (PMID
23940030
)
0
Data Source:
BioGRID
(enzymatic study)
APLF
FBXO25
Gene Name
aprataxin and PNKP like factor
F-box protein 25
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Site Of Double-strand Break
Ubiquitin Ligase Complex
Nucleus
Nucleolus
SCF Ubiquitin Ligase Complex
Molecular Function
Nucleotide Binding
DNA-(apurinic Or Apyrimidinic Site) Lyase Activity
Endodeoxyribonuclease Activity
Protein Binding
3'-5' Exonuclease Activity
Metal Ion Binding
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
Single Strand Break Repair
DNA Catabolic Process, Endonucleolytic
Double-strand Break Repair
Cellular Response To DNA Damage Stimulus
Regulation Of Isotype Switching
Positive Regulation Of DNA Ligation
Nucleic Acid Phosphodiester Bond Hydrolysis
Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
APP
FBXO25
GMCL1
IRX5
LIG4
PARP1
XRCC1
XRCC4
XRCC5
80 interactors:
ADRBK1
ANKRD13A
APLF
AXL
BMX
C11orf63
C19orf57
C6orf106
C7orf50
CDK5RAP2
CDK9
CENPB
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ING3
IRS1
KDR
KRT8
LMCD1
LUC7L
MAT2B
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
Entrez ID
200558
26260
HPRD ID
09848
16439
Ensembl ID
ENSG00000169621
ENSG00000147364
Uniprot IDs
Q8IW19
Q8TCJ0
PDB IDs
2KQB
2KQC
2KQD
2KQE
2KUO
Enriched GO Terms of Interacting Partners
?
Establishment Of Integrated Proviral Latency
Establishment Of Viral Latency
Double-strand Break Repair Via Nonhomologous End Joining
Response To X-ray
Double-strand Break Repair
DNA Repair
Pro-B Cell Differentiation
Immunoglobulin V(D)J Recombination
DNA Ligation Involved In DNA Repair
Cellular Response To DNA Damage Stimulus
Lymphoid Progenitor Cell Differentiation
DNA Ligation
Response To Radiation
Response To Ionizing Radiation
Cellular Response To Lithium Ion
DNA Metabolic Process
Single Strand Break Repair
Hematopoietic Progenitor Cell Differentiation
Cell Differentiation
Isotype Switching
V(D)J Recombination
Hemopoiesis
Neuron Maturation
Response To Lithium Ion
DNA Recombination
Somatic Recombination Of Immunoglobulin Gene Segments
Immune System Development
Regulation Of Neurogenesis
Somatic Diversification Of Immunoglobulins
Cellular Response To Stress
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Generation Of Neurons
B Cell Activation Involved In Immune Response
Neurogenesis
Response To Gamma Radiation
Regulation Of Cell Development
Neuron Apoptotic Process
Leukocyte Differentiation
Organ Development
Immunoglobulin Production
Nucleobase-containing Compound Metabolic Process
Base-excision Repair
Positive Regulation Of Fibroblast Proliferation
Neuron Death
T Cell Differentiation In Thymus
Central Nervous System Development
Multicellular Organismal Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Telomere Maintenance
Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Peptidyl-amino Acid Modification
Cellular Metabolic Process
Cellular Protein Modification Process
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Response To Stress
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Innate Immune Response
Neurotrophin Signaling Pathway
Viral Process
Protein Phosphorylation
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Response To Growth Factor
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Gene Expression
Peptidyl-tyrosine Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Positive Regulation Of Phospholipase C Activity
Phosphorylation
Intracellular Signal Transduction
Regulation Of Cellular Process
Rhythmic Process
Protein Autophosphorylation
Positive Regulation Of Phospholipase Activity
Response To Stimulus
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Organic Substance
Immune Response
Proteasomal Protein Catabolic Process
G1/S Transition Of Mitotic Cell Cycle
Response To UV-A
Peptidyl-serine Autophosphorylation
Regulation Of Phospholipase Activity
Apoptotic Process
Positive Regulation Of Lipase Activity
Defense Response
Protein Metabolic Process
Regulation Of Cell Death
Immune System Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Tagcloud
?
acidic
adp
analogs
ation
binds
chaperone
chaperones
chromatin
collectively
define
eukaryotes
exhibits
h4
histone
histones
homologous
localize
modulates
motif
nap1l
poly
poorly
preferentially
reactions
relaxation
repair
ribose
ribosyl
tetramer
Tagcloud (Difference)
?
acidic
adp
analogs
ation
binds
chaperone
chaperones
chromatin
collectively
define
eukaryotes
exhibits
h4
histone
histones
homologous
localize
modulates
motif
nap1l
poly
poorly
preferentially
reactions
relaxation
repair
ribose
ribosyl
tetramer
Tagcloud (Intersection)
?