APLF and XRCC1

Number of citations of the paper that reports this interaction (PubMedID 17353262)
34

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		APLF	XRCC1
Description		aprataxin and PNKP like factor	X-ray repair cross complementing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of Double-strand Break Site Of DNA Damage	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus ERCC4-ERCC1 Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA Endonuclease Activity Protein Binding Zinc Ion Binding 3'-5' Exonuclease Activity Hydrolase Activity Histone Binding Protein Folding Chaperone Metal Ion Binding Poly-ADP-D-ribose Binding Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding	Damaged DNA Binding Protein Binding Enzyme Binding Oxidized DNA Binding Poly-ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Folding DNA Damage Response Embryo Implantation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Isotype Switching Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Single Strand Break Repair DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Protein ADP-ribosylation Hippocampus Development Response To Hydroperoxide Telomeric DNA-containing Double Minutes Formation Regulation Of Base-excision Repair Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways			Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	21 interacting genes: ANXA1 APEX1 APLF APTX BRCA1 BTRC CHEK2 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 TOPORS UBE2I UHRF2
Entrez ID		200558	7515
HPRD ID		09848	01909
Ensembl ID		ENSG00000169621	ENSG00000073050
Uniprot IDs		Q8IW19	B2RCY5 P18887 Q59HH7
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ 6YN1	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Ligase IV Complex Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Single Strand Break Repair Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Cellular Response To Metal Ion Response To X-ray Neuron Maturation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Double-strand Break Repair DNA Recombination Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Response To Metal Ion Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Oxidized DNA Binding FHA Domain Binding Response To Radiation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Repair Ligase Activity DNA Ligase Activity	Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Base-excision Repair, Gap-filling Nucleoplasm Double-strand Break Repair Macromolecule Metabolic Process Cellular Response To Stress Base-excision Repair Nucleic Acid Metabolic Process Nucleus DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Compound Metabolic Process Response To Stress Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Catalytic Activity Regulation Of DNA Metabolic Process Transferase Activity Regulation Of DNA Repair Post-translational Protein Modification DNA Recombination Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Polynucleotide 3'-phosphatase Activity SUMO Transferase Activity DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Kinase CK2 Complex Response To Oxidative Stress Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Protein Localization To Chromosome PML Body Chromatin Remodeling Protein Modification Process Chromosome Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
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