APLF

Description		aprataxin and PNKP like factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA Endonuclease Activity Protein Binding Zinc Ion Binding 3'-5' Exonuclease Activity Hydrolase Activity Histone Binding Protein Folding Chaperone Metal Ion Binding Poly-ADP-D-ribose Binding Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Folding DNA Damage Response Embryo Implantation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Isotype Switching Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling
Pathways
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		200558
HPRD ID		09848
Ensembl ID		ENSG00000169621
Uniprot IDs		Q8IW19
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ 6YN1
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Ligase IV Complex Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Single Strand Break Repair Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Cellular Response To Metal Ion Response To X-ray Neuron Maturation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Double-strand Break Repair DNA Recombination Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Response To Metal Ion Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Oxidized DNA Binding FHA Domain Binding Response To Radiation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Repair Ligase Activity DNA Ligase Activity
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