APLF

Gene Name		aprataxin and PNKP like factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: APP FBXO25 GMCL1 IRX5 LIG4 PARP1 XRCC1 XRCC4 XRCC5
Entrez ID		200558
HPRD ID		09848
Ensembl ID		ENSG00000169621
Uniprot IDs		Q8IW19
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO
Enriched GO Terms of Interacting Partners?		Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Double-strand Break Repair DNA Repair Pro-B Cell Differentiation Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Response To DNA Damage Stimulus Lymphoid Progenitor Cell Differentiation DNA Ligation Response To Radiation Response To Ionizing Radiation Cellular Response To Lithium Ion DNA Metabolic Process Single Strand Break Repair Hematopoietic Progenitor Cell Differentiation Cell Differentiation Isotype Switching V(D)J Recombination Hemopoiesis Neuron Maturation Response To Lithium Ion DNA Recombination Somatic Recombination Of Immunoglobulin Gene Segments Immune System Development Regulation Of Neurogenesis Somatic Diversification Of Immunoglobulins Cellular Response To Stress Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Generation Of Neurons B Cell Activation Involved In Immune Response Neurogenesis Response To Gamma Radiation Regulation Of Cell Development Neuron Apoptotic Process Leukocyte Differentiation Organ Development Immunoglobulin Production Nucleobase-containing Compound Metabolic Process Base-excision Repair Positive Regulation Of Fibroblast Proliferation Neuron Death T Cell Differentiation In Thymus Central Nervous System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Telomere Maintenance
Tagcloud ?		acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer