APLF and GMCL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		APLF	GMCL1
Description		aprataxin and PNKP like factor	germ cell-less 1, spermatogenesis associated
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of Double-strand Break Site Of DNA Damage	Nucleus Nuclear Matrix
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA Endonuclease Activity Protein Binding Zinc Ion Binding 3'-5' Exonuclease Activity Hydrolase Activity Histone Binding Protein Folding Chaperone Metal Ion Binding Poly-ADP-D-ribose Binding Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Folding DNA Damage Response Embryo Implantation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Isotype Switching Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Germ Cell Development Spermatogenesis Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250
Entrez ID		200558	64395
HPRD ID		09848	13587
Ensembl ID		ENSG00000169621	ENSG00000087338
Uniprot IDs		Q8IW19	Q53SE7 Q96IK5
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ 6YN1
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Ligase IV Complex Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Single Strand Break Repair Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Cellular Response To Metal Ion Response To X-ray Neuron Maturation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Double-strand Break Repair DNA Recombination Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Response To Metal Ion Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Oxidized DNA Binding FHA Domain Binding Response To Radiation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Repair Ligase Activity DNA Ligase Activity	Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process
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