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POT1 and ARRB1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
POT1
ARRB1
Description
protection of telomeres 1
arrestin beta 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Shelterin Complex
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
Membrane
Nuclear Body
Cytoplasmic Vesicle Membrane
Endocytic Vesicle Membrane
Pseudopodium
Cytoplasmic Vesicle
Cell Projection
Molecular Function
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
G Protein-coupled Receptor Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Enzyme Inhibitor Activity
GTPase Activator Activity
Insulin-like Growth Factor Receptor Binding
Protein Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Angiotensin Receptor Binding
Molecular Adaptor Activity
Arrestin Family Protein Binding
Biological Process
Telomere Maintenance
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Positive Regulation Of Telomeric D-loop Disassembly
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Protein Phosphorylation
Desensitization Of G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Internalization
Positive Regulation Of Receptor Internalization
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Sensory Perception
Negative Regulation Of Signal Transduction
Positive Regulation Of Cardiac Muscle Hypertrophy
Protein Transport
Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Rho Protein Signal Transduction
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Intracellular Signal Transduction
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
TGFBR3 regulates TGF-beta signaling
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
24292274
28165464
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
31171785
32109421
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Telomere length (
33941849
)
Obstructive sleep apnea trait (average respiratory event duration) (
26977737
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
58 interacting genes:
ADH6
ADRB1
ADRB2
AGTR1
AP2B1
ARF6
BAG1
BTK
C5AR1
CCR5
CDC42
CLTC
CRHR1
CSK
CXCR2
CYTH2
DVL1
DVL2
EIF2AK4
FGR
FLNA
GNMT
GPR50
GRK2
GSK3B
HCK
HCRTR1
JUN
LIMK1
MAP2K3
MAP2K4
MAPK1
MAPK10
MAPK3
MAPK9
MDM2
NEDD4L
NEK6
NFKBIA
NSF
OPRD1
PDE4D
PIK3R2
POT1
POU2F1
PRDM16
PTH1R
PTHLH
RALGDS
RPL15
SASH1
SLC9A5
SNCA
SREBF2
TIAM1
TP53
TRHR
ZBTB43
Entrez ID
25913
408
HPRD ID
07572
00146
Ensembl ID
ENSG00000128513
ENSG00000137486
Uniprot IDs
A8MTK3
Q5MJ33
Q9NUX5
B7Z1Q3
P49407
PDB IDs
1XJV
3KJO
3KJP
5H65
5UN7
7QXB
7QXS
7S1O
7S1T
7S1U
8SH0
8SH1
8SOJ
8SOK
2IV8
6PWC
6TKO
6UP7
7R0C
7R0J
7SRS
8AS2
8AS3
8AS4
8JRV
8WRZ
9II2
9II3
Enriched GO Terms of Interacting Partners
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Cytoplasm
Cytosol
Extracellular Exosome
Cytoskeleton Organization
Actin Filament Organization
Cytoskeleton
Protein Binding
Cadherin Binding
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Supramolecular Fiber Organization
Cellular Response To Heat
Actin Binding
Carbohydrate Catabolic Process
Response To Heat
Pyruvate Metabolic Process
Organelle Organization
Glycolytic Process
Nucleoside Phosphate Metabolic Process
ADP Catabolic Process
Vesicle
Purine Nucleotide Metabolic Process
Identical Protein Binding
Generation Of Precursor Metabolites And Energy
Purine Ribonucleoside Diphosphate Catabolic Process
Small Molecule Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
ADP Metabolic Process
Response To Temperature Stimulus
Nucleoside Diphosphate Catabolic Process
Purine Nucleotide Catabolic Process
Ficolin-1-rich Granule Lumen
Glucose Metabolic Process
Microtubule Cytoskeleton Organization
Nucleoside Phosphate Catabolic Process
Actin Filament-based Process
Actin Cytoskeleton Organization
Monocarboxylic Acid Metabolic Process
Nucleotide Metabolic Process
Negative Regulation Of Cellular Component Organization
Cytoskeletal Protein Binding
Protein Sequestering Activity
Focal Adhesion
Catabolic Process
Monosaccharide Metabolic Process
Actin Monomer Binding
Cellular Response To Raffinose
Nucleotide Catabolic Process
Organic Acid Metabolic Process
Signal Transduction
Intracellular Signaling Cassette
Cell Surface Receptor Signaling Pathway
Regulation Of Transport
Regulation Of Signaling
Intracellular Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Regulation Of Biological Quality
Plasma Membrane
Protein Kinase Activity
Cytosol
Regulation Of Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Fc Receptor Signaling Pathway
Kinase Activity
Regulation Of Intracellular Signal Transduction
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
Endocytosis
Positive Regulation Of Cellular Component Organization
Regulation Of Vesicle-mediated Transport
G Protein-coupled Receptor Activity
Regulation Of Cellular Component Organization
Phosphorylation
Positive Regulation Of Organelle Organization
Immune Response-regulating Signaling Pathway
Import Into Cell
Positive Regulation Of Signaling
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Endocytosis
Protein Serine/threonine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Receptor Internalization
Positive Regulation Of Cell Communication
Regulation Of Cytoskeleton Organization
MAP Kinase Activity
Regulation Of MAPK Cascade
Regulation Of Organelle Organization
Protein Serine Kinase Activity
Positive Regulation Of Metabolic Process
Phosphotyrosine Residue Binding
Positive Regulation Of Intracellular Signal Transduction
Neuronal Dense Core Vesicle
MAPK Cascade
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cellular Localization
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Tagcloud (Intersection)
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