ARRB1 and AGTR1

Number of citations of the paper that reports this interaction (PMID 15611106)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ARRB1	AGTR1
Gene Name		arrestin, beta 1	angiotensin II receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding	Angiotensin Type I Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Vasodilation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Valsartan Olmesartan Losartan Candesartan Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan Azilsartan medoxomil
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43	20 interactors: ADRBK1 ADRBK2 AGT AGTRAP ARRB1 ARRB2 BDKRB2 DNAJC14 EGFR GPRASP1 GRK5 HRAS JAK2 NOS3 PDE6H PLCG1 RAB5A RAF1 THOP1 ZBTB16
Entrez ID		408	185
HPRD ID		00146	00107
Ensembl ID		ENSG00000137486	ENSG00000144891
Uniprot IDs		B7Z1Q3 P49407	D3DNG8 P30556 Q53YY0 Q6NUP5 Q8TBK4
PDB IDs		2IV8	1ZV0
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process	Regulation Of Signaling Positive Regulation Of MAPK Cascade Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Receptor Internalization Negative Regulation Of Signaling Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Negative Regulation Of Cell Death Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Phosphorylation Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transport Activation Of Phospholipase C Activity Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration
Tagcloud ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	125b affliction altering angiogenic anomalously bak1 bak1in continues differentiate downregulates dtl etiology expressions grow hnscc mechanistic meis1 mirna mirnas modes ones qrt seq tp53 tyms unravel unreported upregulates vis
Tagcloud (Difference) ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	125b affliction altering angiogenic anomalously bak1 bak1in continues differentiate downregulates dtl etiology expressions grow hnscc mechanistic meis1 mirna mirnas modes ones qrt seq tp53 tyms unravel unreported upregulates vis
Tagcloud (Intersection) ?