POT1 and PGLS

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		POT1	PGLS
Gene Name		protection of telomeres 1	6-phosphogluconolactonase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding	6-phosphogluconolactonase Activity Monosaccharide Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation	Carbohydrate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Oxidative Branch Pathogenesis Small Molecule Metabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)
Drugs
Diseases
GWAS
Protein-Protein Interactions		166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	16 interactors: EWSR1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 MDFI NOTCH2NL PLSCR1 POT1 RBPMS RCHY1 TERF1 TERF2IP
Entrez ID		25913	25796
HPRD ID		07572	12001
Ensembl ID		ENSG00000128513	ENSG00000130313
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	O95336
PDB IDs		1XJV 3KJO 3KJP
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Regulation Of Telomerase Activity Negative Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Telomere Formation Via Telomerase Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protection From Non-homologous End Joining At Telomere Regulation Of Nitrogen Compound Metabolic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Helicase Activity Phosphatidylserine Biosynthetic Process Regulation Of Protein Import Into Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleocytoplasmic Transport Replicative Cell Aging Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Nuclear Cell Cycle DNA Replication Phospholipid Scrambling Positive Regulation Of Telomere Maintenance Regulation Of Metabolic Process Regulation Of Intracellular Protein Transport
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	100ng 1r 24h antidiabetic ap consisting elicited expressions extensively granulosa incubated insr insulin irs kappabreporter luciferase lutein mek metformin ovary p70 pdk1 phosphoinositide polycystic porcine raf rapamycin steroidogenesis tor
Tagcloud (Difference) ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	100ng 1r 24h antidiabetic ap consisting elicited expressions extensively granulosa incubated insr insulin irs kappabreporter luciferase lutein mek metformin ovary p70 pdk1 phosphoinositide polycystic porcine raf rapamycin steroidogenesis tor
Tagcloud (Intersection) ?