ARRB1 and MAPK10

Number of citations of the paper that reports this interaction (PubMedID 19782076)
0

Data Source:
BioGRID (unspecified method)

		ARRB1	MAPK10
Description		arrestin beta 1	mitogen-activated protein kinase 10
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Membrane Nuclear Body Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Cell Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Molecular Adaptor Activity Arrestin Family Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Sensory Perception Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Protein Transport Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction	MAPK Cascade Protein Phosphorylation Signal Transduction JNK Cascade Response To Light Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Cellular Senescence
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors
Drugs			Minocycline Pyrazolanthrone Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Phosphoaminophosphonic Acid-Adenylate Ester N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline Fostamatinib Halicin
Diseases
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Cobalt levels ( 26025379) Diisocyanate-induced asthma ( 25918132) Gait speed in old age ( 28077804) Liver enzyme levels (alanine transaminase) ( 22001757 33972514) Multiple sclerosis ( 31604244) Peripheral artery disease ( 25009551) Response to cytidine analogues (gemcitabine) ( 24483146) Triglyceride levels ( 32154731 32203549)
Interacting Genes		58 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CRHR1 CSK CXCR2 CYTH2 DVL1 DVL2 EIF2AK4 FGR FLNA GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEDD4L NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SNCA SREBF2 TIAM1 TP53 TRHR ZBTB43	40 interacting genes: APP ARRB1 ARRB2 ATF2 BCL2L11 CDK5 CDKN1B CDKN2A CDKN2C CEP290 CREBBP DUSP10 DUSP16 DUSP9 ELK1 FBXO7 GTF3C1 HAX1 HDAC9 HNRNPK HRAS JUN KIF26A KIF5A LDHA MAP2K4 MAPK8IP2 MAPK8IP3 MAPKBP1 MAPT MCL1 PKMYT1 PLIN2 RELA SH3BP5 STMN2 TNIP1 TP53 UBE3A UNC119
Entrez ID		408	5602
HPRD ID		00146	04207
Ensembl ID		ENSG00000137486	ENSG00000109339
Uniprot IDs		B7Z1Q3 P49407	A0A286YEQ0 A0A286YF97 D6RJF9 F8W9R5 P53779 Q499Y8
PDB IDs		2IV8 6PWC 6TKO 6UP7 7R0C 7R0J 7SRS 8AS2 8AS3 8AS4 8JRV 8WRZ 9II2 9II3	1JNK 1PMN 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N 3KVX 3OXI 3OY1 3PTG 3RTP 3TTI 3TTJ 3V6R 3V6S 4H36 4H39 4H3B 4KKE 4KKG 4KKH 4U79 4W4V 4W4W 4W4X 4W4Y 4WHZ 4X21 4Y46 4Y5H 4Z9L 6EKD 6EMH 6EQ9 7KSI 7KSJ 7KSK 7ORE 7ORF 7S1N 7YL1 8BZP 8ENJ 8VNX 8VO4 8VS0 8VTF 8WGF
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Transport Regulation Of Signaling Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane Protein Kinase Activity Cytosol Regulation Of Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Protein Phosphorylation Regulation Of Multicellular Organismal Process Endocytosis Positive Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport G Protein-coupled Receptor Activity Regulation Of Cellular Component Organization Phosphorylation Positive Regulation Of Organelle Organization Immune Response-regulating Signaling Pathway Import Into Cell Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Endocytosis Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Receptor Internalization Positive Regulation Of Cell Communication Regulation Of Cytoskeleton Organization MAP Kinase Activity Regulation Of MAPK Cascade Regulation Of Organelle Organization Protein Serine Kinase Activity Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Neuronal Dense Core Vesicle MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Localization	Cytoplasm Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Neuron Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling JUN Kinase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Nucleus Regulation Of Apoptotic Process MAPK Cascade Regulation Of Programmed Cell Death Cytosol Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding JNK Cascade MAP Kinase Tyrosine Phosphatase Activity Cellular Senescence Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Tyrosine/threonine Phosphatase Activity Protein Kinase Binding Programmed Cell Death Regulation Of Growth Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of JNK Cascade Regulation Of Post-translational Protein Modification Negative Regulation Of Multicellular Organismal Process Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Post-translational Protein Modification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription General Transcription Initiation Factor Binding Nucleoplasm Regulation Of Apoptotic Signaling Pathway
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