POT1 and YWHAE

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		POT1	YWHAE
Gene Name		protection of telomeres 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Mitochondrion Cytosol Kinesin Complex Focal Adhesion Membrane Axon Cytoplasmic Vesicle Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding	Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Histone Deacetylase Binding Ion Channel Binding Poly(A) RNA Binding Protein Heterodimerization Activity Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Neuron Migration Regulation Of Heart Rate By Hormone Protein Targeting Apoptotic Process Organelle Organization Viral Process Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	HSF1 activation Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane G2/M Transition Activation of BH3-only proteins Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Programmed Cell Death Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Assembly of the primary cilium Cellular response to heat stress Regulation of HSF1-mediated heat shock response Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Signaling by Hippo Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation NADE modulates death signalling Mitotic G2-G2/M phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	107 interactors: ABL1 ACD AKAP13 ANKHD1-EIF4EBP3 ARHGEF2 ARHGEF28 ATXN1 BAD BCR CALM1 CAP2 CASP3 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP95 CGNL1 CHAF1A COX2 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GTF2B HDAC4 HDAC5 HIVEP2 HSF1 IGF1R IL7R ING1 IRS1 IRS2 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KRT18 LRMP MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MDM4 MSL2 MST1R MYH10 NCOR2 NDEL1 NGFRAP1 PAPOLA PNLIP POT1 PRKCG RAF1 RAP1GAP2 RASAL3 RASGRF1 REM1 RGS3 RIN1 RPGR SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SNCA SORBS2 SRC SSFA2 SYN2 TAF7 TAZ TBC1D3F TBP TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF839
Entrez ID		25913	7531
HPRD ID		07572	05457
Ensembl ID		ENSG00000128513	ENSG00000108953
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	P62258
PDB IDs		1XJV 3KJO 3KJP	2BR9 3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process	Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor System Development Neurotrophin TRK Receptor Signaling Pathway Developmental Process Neurotrophin Signaling Pathway Negative Regulation Of Phosphorylation Response To Organic Substance Anatomical Structure Development Multicellular Organismal Development Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Programmed Cell Death Regulation Of Cellular Component Organization Cell Death Death Cellular Response To Organonitrogen Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Difference) ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Intersection) ?