ARRB1 and MAP2K4

Number of citations: 0 (PubMedID 19782076)
Data Source: BioGRID (unspecified method)

		ARRB1	MAP2K4
Name		arrestin beta 1	mitogen-activated protein kinase kinase 4
Structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Membrane Nuclear Body Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Cell Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Molecular Adaptor Activity Arrestin Family Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Molecular Adaptor Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Sensory Perception Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Protein Transport Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction	MAPK Cascade Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Cellular Response To Stress Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		None	Pimasertib
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 )	Asthma ( 32296059 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 31152163 ) Response to amphetamines ( 22952603 ) Serum alkaline phosphatase levels ( 33339817 )
Novel Interactors		None recorded	1 novel interactors: MAPK7
Interacting Genes		58 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CRHR1 CSK CXCR2 CYTH2 DVL1 DVL2 EIF2AK4 FGR FLNA GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEDD4L NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SNCA SREBF2 TIAM1 TP53 TRHR ZBTB43	44 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC ZDHHC17
Entrez ID		408	6416
HPRD ID		00146	03213
Ensembl ID		ENSG00000137486	ENSG00000065559
Uniprot IDs		B7Z1Q3 P49407	P45985
PDB IDs		2IV8 6PWC 6TKO 6UP7 7R0C 7R0J 7SRS 8AS2 8AS3 8AS4 8JRV 8WRZ 9II2 9II3	3ALN 3ALO 3VUT 8YP5
GO Terms Enriched among Interactors		Signal Transduction Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Transport Regulation Of Signaling Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane Protein Kinase Activity Cytosol Regulation Of Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Protein Phosphorylation Regulation Of Multicellular Organismal Process Endocytosis Positive Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport G Protein-coupled Receptor Activity Regulation Of Cellular Component Organization Phosphorylation Positive Regulation Of Organelle Organization Immune Response-regulating Signaling Pathway Import Into Cell Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Endocytosis Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Receptor Internalization Positive Regulation Of Cell Communication Regulation Of Cytoskeleton Organization MAP Kinase Activity Regulation Of MAPK Cascade Regulation Of Organelle Organization Protein Serine Kinase Activity Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Neuronal Dense Core Vesicle MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Localization	MAPK Cascade MAP Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Protein Kinase Activity Kinase Activity Regulation Of MAPK Cascade Intracellular Signal Transduction JNK Cascade MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction ATP Binding Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Transferase Activity Stress-activated MAPK Cascade Signal Transduction Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytoplasm Regulation Of Signal Transduction Nucleotide Binding JUN Kinase Kinase Kinase Activity Protein Modification Process Cytosol P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Cellular Senescence JUN Kinase Activity Regulation Of MAP Kinase Activity Phosphate-containing Compound Metabolic Process Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway