POT1 and PFKP

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		POT1	PFKP
Name		protection of telomeres 1	phosphofructokinase, platelet
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Fructose-6-phosphate Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Canonical Glycolysis Cellular Response To Leukemia Inhibitory Factor
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Glycolysis
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464 ) Cutaneous malignant melanoma ( 26237428 ) Leukocyte telomere length ( 31171785 32109421 ) Refractive error ( 32231278 ) Response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Telomere length ( 33941849 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Body size at age 10 ( 32376654 ) Disc degeneration (lumbar) ( 22993228 ) HDL cholesterol levels in HIV infection ( 33109212 ) Hippocampal volume in mild cognitive impairment ( 29274321 ) Mean platelet volume ( 32888494 ) Scalp hair shape ( 26926045 ) Subclinical trait of interstitial lung disease (percentage of high attenuation areas on CT scan) ( 28521775 )
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	15 interacting genes: ACD AGO2 AKT1 DYNLL1 EGFR KAT5 LINC00632 NUTF2 POT1 SUMO2 TERF1 TINF2 TRIM21 VHL WNK1
Entrez ID		25913	5214
HPRD ID		07572	01384
Ensembl ID		ENSG00000128513	ENSG00000067057
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	A0A7I2V3Z0 A0A8V8TMY4 B1APP6 Q01813
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2 7TFF
GO Terms Enriched among Interactors		Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Regulation Of DNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process RNA-templated DNA Biosynthetic Process Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Positive Regulation Of Metabolic Process Positive Regulation Of Organelle Organization Telomere Organization Positive Regulation Of Cell Cycle Establishment Of Protein Localization To Organelle Regulation Of Establishment Of Protein Localization To Telomere Organelle Organization Activation-induced Cell Death Of T Cells Regulation Of Autophagy Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Primary Metabolic Process Negative Regulation Of Catabolic Process Chromosome, Telomeric Region Nitric-oxide Synthase Regulator Activity Chromosome Telomeric D-loop Disassembly DNA Metabolic Process Positive Regulation Of Cellular Component Organization