POT1 and GAMT

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		POT1	GAMT
Gene Name		protection of telomeres 1	guanidinoacetate N-methyltransferase
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding	Methyltransferase Activity Guanidinoacetate N-methyltransferase Activity
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Organ Morphogenesis Methylation Cellular Nitrogen Compound Metabolic Process Regulation Of Multicellular Organism Growth Small Molecule Metabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Metabolism of amino acids and derivatives Creatine metabolism
Drugs			Creatine Guanidine S-Adenosyl-L-Homocysteine N-[Amino(Imino)Methyl]Glycine
Diseases
GWAS
Protein-Protein Interactions		166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	5 interactors: CSNK2B FOS POT1 TERF1 TERF2IP
Entrez ID		25913	2593
HPRD ID		07572	03142
Ensembl ID		ENSG00000128513	ENSG00000130005
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	Q14353
PDB IDs		1XJV 3KJO 3KJP	3ORH
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process DNA Replication DNA Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Organelle Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Conditioned Taste Aversion Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transferase Activity Adiponectin-activated Signaling Pathway Homeostatic Process Aging Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Endothelial Tube Morphogenesis Positive Regulation Of Telomere Maintenance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	accelerate adipocyte anabolism antagonized assembling concert drive eoc fabp4 fao fas guanidinoacetate hgs hypothesize omentum ovca p63 serous slug smads snail srebps sterol summarizing suppressive tp53 transformative twist upregulates
Tagcloud (Difference) ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	accelerate adipocyte anabolism antagonized assembling concert drive eoc fabp4 fao fas guanidinoacetate hgs hypothesize omentum ovca p63 serous slug smads snail srebps sterol summarizing suppressive tp53 transformative twist upregulates
Tagcloud (Intersection) ?