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POT1 and MVP
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
POT1
MVP
Description
protection of telomeres 1
major vault protein
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Shelterin Complex
Extracellular Region
Nucleus
Nuclear Pore
Cytoplasm
Cytosol
Cytoskeleton
Membrane
Secretory Granule Lumen
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Identical Protein Binding
Biological Process
Telomere Maintenance
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Positive Regulation Of Telomeric D-loop Disassembly
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Cell Population Proliferation
Protein Transport
Negative Regulation Of Protein Autophosphorylation
ERBB Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
MRNA Transport
Negative Regulation Of Protein Tyrosine Kinase Activity
Protein Activation Cascade
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Neutrophil degranulation
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
24292274
28165464
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
31171785
32109421
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Telomere length (
33941849
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
69 interacting genes:
ADAMTSL4
BANP
C1orf94
CALCOCO2
CAMK2B
CKAP4
DISC1
DLX2
DTX2
EPHX2
ESR1
FMR1
FNDC3B
FXR1
FXR2
GIT2
GOLGA2
HP
HSPA13
IHO1
KCTD9
KPNA2
KPNA3
MDFI
MEOX1
MEOX2
MID2
MRTFA
MT-CYB
NNT
NOTCH2NLA
NRF1
NTAQ1
PARP4
PIH1D2
PLSCR1
POT1
PSTPIP1
PTEN
PTPN11
RAB3IP
RBPMS
REL
RHOXF2
RIMBP3
RNF10
RNF111
SAXO1
SERTAD1
SKIL
SLC2A4
STN1
TCF4
TENT5C
TFCP2
TLE5
TOLLIP
TP53
TRAF2
TRIM27
TRIM42
TRIP13
TRIP6
TSPOAP1
UBC
UBTD2
VAC14
ZBTB32
ZMIZ2
Entrez ID
25913
9961
HPRD ID
07572
05475
Ensembl ID
ENSG00000128513
ENSG00000013364
Uniprot IDs
A8MTK3
Q5MJ33
Q9NUX5
Q14764
X5D2M8
X5D7K9
X5DNU0
PDB IDs
1XJV
3KJO
3KJP
5H65
5UN7
7QXB
7QXS
7S1O
7S1T
7S1U
8SH0
8SH1
8SOJ
8SOK
1Y7X
9BW5
9BW6
9BW7
9MXH
9MXV
Enriched GO Terms of Interacting Partners
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Cytoplasm
Cytosol
Extracellular Exosome
Cytoskeleton Organization
Actin Filament Organization
Cytoskeleton
Protein Binding
Cadherin Binding
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Supramolecular Fiber Organization
Cellular Response To Heat
Actin Binding
Carbohydrate Catabolic Process
Response To Heat
Pyruvate Metabolic Process
Organelle Organization
Glycolytic Process
Nucleoside Phosphate Metabolic Process
ADP Catabolic Process
Vesicle
Purine Nucleotide Metabolic Process
Identical Protein Binding
Generation Of Precursor Metabolites And Energy
Purine Ribonucleoside Diphosphate Catabolic Process
Small Molecule Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
ADP Metabolic Process
Response To Temperature Stimulus
Nucleoside Diphosphate Catabolic Process
Purine Nucleotide Catabolic Process
Ficolin-1-rich Granule Lumen
Glucose Metabolic Process
Microtubule Cytoskeleton Organization
Nucleoside Phosphate Catabolic Process
Actin Filament-based Process
Actin Cytoskeleton Organization
Monocarboxylic Acid Metabolic Process
Nucleotide Metabolic Process
Negative Regulation Of Cellular Component Organization
Cytoskeletal Protein Binding
Protein Sequestering Activity
Focal Adhesion
Catabolic Process
Monosaccharide Metabolic Process
Actin Monomer Binding
Cellular Response To Raffinose
Nucleotide Catabolic Process
Organic Acid Metabolic Process
Identical Protein Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Positive Regulation Of Biosynthetic Process
Cytoplasm
Regulation Of Neurogenesis
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
PML Body
Positive Regulation Of RNA Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Nervous System Development
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Nucleus
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Translation Regulator Activity
Regulation Of Neuronal Synaptic Plasticity
TFIIB-class Transcription Factor Binding
Viral Penetration Into Host Nucleus
Negative Regulation Of Telomere Maintenance Via Telomerase
Benzodiazepine Receptor Binding
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Strand Annealing Activity
Regulation Of MiRNA-mediated Gene Silencing
Somite Specification
Dentate Gyrus Development
Single-stranded Telomeric DNA Binding
MRNA 3'-UTR Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-transcriptional Gene Silencing
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Regulation Of Viral Process
Protein Binding
Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Chromosome Organization
Positive Regulation Of Neurogenesis
Intracellular Membraneless Organelle
Presynapse
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Catabolic Process
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