ARRB1 and PTHLH

Number of citations of the paper that reports this interaction (PMID 12220636)
1

Data Source:
HPRD (in vivo)

		ARRB1	PTHLH
Gene Name		arrestin, beta 1	parathyroid hormone-like hormone
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding	Hormone Activity Peptide Hormone Receptor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Skeletal System Development Endochondral Ossification Osteoblast Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Endoderm Development Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Protein Processing Positive Regulation Of CAMP Biosynthetic Process Epithelial Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Surfactant Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity CAMP Metabolic Process Lung Alveolus Development Mammary Gland Bud Elongation Nipple Sheath Formation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Breast cancer ( 23535729 23535733) Breast size ( 22747683)
Protein-Protein Interactions		52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43	6 interactors: ARRB1 CDK2 IL6 KLK3 KPNB1 PTH1R
Entrez ID		408	5744
HPRD ID		00146	01348
Ensembl ID		ENSG00000137486	ENSG00000087494
Uniprot IDs		B7Z1Q3 P49407	P12272 Q53XY9
PDB IDs		2IV8	1BZG 1ET3 1M5N 3FFD 3H3G
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Positive Regulation Of Acute Inflammatory Response Bone Remodeling Regulation Of Protein Processing Positive Regulation Of DNA Replication Regulation Of Acute Inflammatory Response Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Glucagon Secretion Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Tissue Remodeling Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Factor XII Activation Hepatic Immune Response Positive Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of Chemokine Biosynthetic Process Neutrophil Apoptotic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Protein Secretion Response To Reactive Oxygen Species Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity T-helper 17 Cell Differentiation Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death
Tagcloud ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand
Tagcloud (Difference) ?		11q13 adrenergic apparently ark ark1 arrestin beta coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map member multigene named occupied phosphorylates	2p11 3p13 assigned atrophy cd4 chromosomal del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand
Tagcloud (Intersection) ?		chromosome mapping