Wiki-Pi
About
Search
People
Updates
Search
POT1 and MADD
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
POT1
MADD
Description
protection of telomeres 1
MAP kinase activating death domain
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Shelterin Complex
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Axon
Cell Projection
Molecular Function
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
Guanyl-nucleotide Exchange Factor Activity
Death Receptor Binding
Protein Binding
Protein Kinase Activator Activity
Biological Process
Telomere Maintenance
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Positive Regulation Of Telomeric D-loop Disassembly
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Rab Protein Signal Transduction
Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Regulation Of Cell Cycle
Execution Phase Of Apoptosis
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
24292274
28165464
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
31171785
32109421
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Telomere length (
33941849
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
C-reactive protein levels (
30388399
)
Chronic kidney disease (
26831199
)
Chronotype (
30696823
)
Corneal astigmatism (
29422769
)
Fasting blood glucose (
20081858
22581228
25631608
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fasting blood proinsulin levels (
23263489
)
Fasting glucose (
34059833
)
General factor of neuroticism (
30867560
)
Glaucoma (primary open-angle) (
29891935
)
Glycemic traits (pleiotropy) (
31021400
)
HDL cholesterol (
25961943
19060911
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
HDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Insulin-related traits (multivariate analysis) (
32002517
)
Loneliness (
29970889
)
Loneliness (MTAG) (
29970889
)
Monocyte percentage of white cells (
32888494
)
Neuroticism (
29255261
)
Proinsulin levels (
21873549
)
Refractive error (
32231278
)
Interacting Genes
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
12 interacting genes:
NPDC1
PCNT
PIDD1
POT1
PTPRN
RB1CC1
RBM11
TNFRSF10A
TNFRSF10B
TNFRSF1A
VPS13D
YWHAZ
Entrez ID
25913
8567
HPRD ID
07572
04664
Ensembl ID
ENSG00000128513
ENSG00000110514
Uniprot IDs
A8MTK3
Q5MJ33
Q9NUX5
A0A0A0MRB5
A0A0U1RR25
A0A9L9PXF1
A0A9L9PXN0
A0A9L9PXZ0
A0A9L9PXZ3
A0A9L9PY18
A0A9L9PY22
Q8WXG6
PDB IDs
1XJV
3KJO
3KJP
5H65
5UN7
7QXB
7QXS
7S1O
7S1T
7S1U
8SH0
8SH1
8SOJ
8SOK
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Cytosol
Extracellular Exosome
Cytoskeleton Organization
Actin Filament Organization
Cytoskeleton
Protein Binding
Cadherin Binding
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Supramolecular Fiber Organization
Cellular Response To Heat
Actin Binding
Carbohydrate Catabolic Process
Response To Heat
Pyruvate Metabolic Process
Organelle Organization
Glycolytic Process
Nucleoside Phosphate Metabolic Process
ADP Catabolic Process
Vesicle
Purine Nucleotide Metabolic Process
Identical Protein Binding
Generation Of Precursor Metabolites And Energy
Purine Ribonucleoside Diphosphate Catabolic Process
Small Molecule Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
ADP Metabolic Process
Response To Temperature Stimulus
Nucleoside Diphosphate Catabolic Process
Purine Nucleotide Catabolic Process
Ficolin-1-rich Granule Lumen
Glucose Metabolic Process
Microtubule Cytoskeleton Organization
Nucleoside Phosphate Catabolic Process
Actin Filament-based Process
Actin Cytoskeleton Organization
Monocarboxylic Acid Metabolic Process
Nucleotide Metabolic Process
Negative Regulation Of Cellular Component Organization
Cytoskeletal Protein Binding
Protein Sequestering Activity
Focal Adhesion
Catabolic Process
Monosaccharide Metabolic Process
Actin Monomer Binding
Cellular Response To Raffinose
Nucleotide Catabolic Process
Organic Acid Metabolic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Death Receptor Activity
TRAIL Binding
Cellular Response To Mechanical Stimulus
TRAIL-activated Apoptotic Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Cell Death
Programmed Cell Death
Response To Mechanical Stimulus
Activation Of Protein Kinase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
TRAIL Receptor Activity
Ribophagy
Positive Regulation Of DNA Strand Elongation
Positive Regulation Of Telomeric D-loop Disassembly
G-rich Single-stranded DNA Binding
Signaling Receptor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Synaptic Target Recognition
Positive Regulation Of Telomeric Loop Disassembly
Dense Core Granule Maturation
8-hydroxy-2'-deoxyguanosine DNA Binding
Telomeric G-quadruplex DNA Binding
Endopeptidase Complex
Response To Stress
Secretory Granule Maturation
Positive Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Extracellular Matrix Constituent Secretion
Pulmonary Valve Development
Tumor Necrosis Factor Receptor Superfamily Complex
Telomeric D-loop Binding
Telomere Assembly
Protein Retention In Golgi Apparatus
Cellular Response To Stress
Golgi Reassembly
Single-stranded Telomeric DNA Binding
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Aortic Valve Development
Semi-lunar Valve Development
Phosphoserine Residue Binding
Positive Regulation Of Kinase Activity
Shelterin Complex
Organelle Organization
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?