ARRB1 and C5AR1

Number of citations of the paper that reports this interaction (PMID 12464600)
12

Data Source:
HPRD (in vivo)

		ARRB1	C5AR1
Gene Name		arrestin, beta 1	complement component 5a receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Apical Part Of Cell
	Molecular Function	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding	Complement Component C5a Binding Complement Component C5a Receptor Activity C5a Anaphylatoxin Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Activation Of MAPK Activity Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Cell Proliferation In Hindbrain Neutrophil Chemotaxis Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43	7 interactors: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS
Entrez ID		408	728
HPRD ID		00146	00224
Ensembl ID		ENSG00000137486	ENSG00000197405
Uniprot IDs		B7Z1Q3 P49407	P21730
PDB IDs		2IV8
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process	Positive Regulation Of MAPK Cascade Negative Regulation Of Interleukin-6 Production Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To External Stimulus Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Immune System Process Regulation Of Interleukin-6 Production Blood Coagulation Hemostasis Positive Regulation Of ERK1 And ERK2 Cascade G-protein Coupled Receptor Internalization Positive Regulation Of Signal Transduction Regulation Of Cytokine Production Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Receptor Internalization Regulation Of Body Fluid Levels Cell Chemotaxis Wound Healing Chemotaxis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Migration Regulation Of Phosphorus Metabolic Process Platelet Activation Cell Activation Negative Regulation Of Cytokine Production Response To Wounding Negative Regulation Of Chemotaxis Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Endopeptidase Activity Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Peptidase Activity Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Regulation Of Immune Response Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Stress Receptor Internalization Positive Regulation Of Protein Modification Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Phosphorylation
Tagcloud ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?