POT1 and TPP1

Number of citations of the paper that reports this interaction (PMID 25172512)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		POT1	TPP1
Gene Name		protection of telomeres 1	tripeptidyl peptidase I
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Mitochondrion Lysosome Melanosome Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Peptide Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Peptide Catabolic Process Cellular Protein Metabolic Process Bone Resorption Neuromuscular Process Controlling Balance
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	6 interactors: CTC1 NMB OBFC1 POT1 TERT TINF2
Entrez ID		25913	1200
HPRD ID		07572	06415
Ensembl ID		ENSG00000128513	ENSG00000166340
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	O14773
PDB IDs		1XJV 3KJO 3KJP	1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process	Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Assembly Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Homeostatic Process Telomere Formation Via Telomerase Positive Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization DNA Metabolic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Replicative Senescence Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Replication Cell Aging Negative Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Positive Regulation Of Metabolic Process Negative Regulation Of RNA Interference Regulation Of Protein ADP-ribosylation Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Positive Regulation Of Helicase Activity Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Bone Marrow Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Protein Glycosylation
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip