POT1 and WIPI2

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		POT1	WIPI2
Name		protection of telomeres 1	WD repeat domain, phosphoinositide interacting 2
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Protein-containing Complex Phagophore Assembly Site Membrane
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Response To Stress Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Glycophagy Autophagosome Maturation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Macroautophagy
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464 ) Cutaneous malignant melanoma ( 26237428 ) Leukocyte telomere length ( 31171785 32109421 ) Refractive error ( 32231278 ) Response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Telomere length ( 33941849 )	Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117 ) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117 ) High light scatter reticulocyte count ( 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 )
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	18 interacting genes: ARL6IP1 ATG16L1 COPS6 CRYAA DDB1 DGAT2L6 FKBP7 HUWE1 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP
Entrez ID		25913	26100
HPRD ID		07572	15679
Ensembl ID		ENSG00000128513	ENSG00000157954
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	Q9Y4P8
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK	7F69 7MU2 7XFR
GO Terms Enriched among Interactors		Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process	Organelle Organization Positive Regulation Of Catabolic Process Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Shelterin Complex Regulation Of NADP Metabolic Process Positive Regulation Of Autophagy Regulation Of Autophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Cellular Component Organization Protein-macromolecule Adaptor Activity Cellular Response To L-leucine Telomere Capping Response To L-leucine Autophagosome Assembly Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Organization Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase III Telomeric DNA Binding Protein-containing Complex Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Positive Regulation Of Small Molecule Metabolic Process Macroautophagy Regulation Of Cell Growth Chromosome, Telomeric Region Vacuole Organization Positive Regulation Of ATP Metabolic Process GTPase Binding Negative Regulation Of Telomere Maintenance DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Vacuole-isolation Membrane Contact Site Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Identical Protein Binding Regulation Of Glycolytic Process Cytoplasmic Vesicle