POT1 and ALDH1A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		POT1	ALDH1A1
Description		protection of telomeres 1	aldehyde dehydrogenase 1 family member A1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex	Cytoplasm Cytosol Axon Cell Projection Synapse Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	Nucleotide Binding Retinal Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NAD+) Activity GTPase Activator Activity Androgen Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity Aminobutyraldehyde Dehydrogenase (NAD+) Activity NAD Binding 3-deoxyglucosone Dehydrogenase Activity Acetaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Retinoid Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Fructosamine Catabolic Process Maintenance Of Lens Transparency Retinol Metabolic Process Cellular Detoxification Of Aldehyde Negative Regulation Of Cold-induced Thermogenesis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	RA biosynthesis pathway Fructose catabolism Ethanol oxidation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs			NADH Vitamin A Tretinoin 1,4-Dithiothreitol
Diseases
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 31171785 32109421) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Telomere length ( 33941849)	Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Sensorimotor dexterity ( 31596458)
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	4 interacting genes: ALDH2 BRCA1 NUPR1 POT1
Entrez ID		25913	216
HPRD ID		07572	00001
Ensembl ID		ENSG00000128513	ENSG00000165092
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	P00352 V9HW83
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK	4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI 6DUM 7JWS 7JWT 7JWU 7JWV 7JWW 7UM9 8D46 8DNO 8ENE 8PVH 8T0N 8T0T 8WFQ
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process	Regulation Of Cellular Response To Stress Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chondroitin Sulfate Proteoglycan Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Small Molecule Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Telomeric Loop Disassembly Negative Regulation Of Cellular Component Organization Aldehyde Dehydrogenase [NAD(P)+] Activity Regulation Of Dopamine Biosynthetic Process Carboxylesterase Activity BRCA1-B Complex Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Receptor Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Oxidative Phosphorylation Cellular Response To Indole-3-methanol Single-stranded Telomeric DNA Binding Negative Regulation Of Centriole Replication Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Indole-3-methanol Regulation Of DNA Repair Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere Regulation Of Female Gonad Development Regulation Of Organelle Assembly BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DEAD/H-box RNA Helicase Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ethanol Metabolic Process Aldehyde Catabolic Process Aldehyde Dehydrogenase (NAD+) Activity
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