POT1 and MICA

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		POT1	MICA
Description		protection of telomeres 1	MHC class I polypeptide-related sequence A
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex	Extracellular Space Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	Protein Binding Beta-2-microglobulin Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Immune Response To Tumor Cell Immune Response DNA Damage Response Signal Transduction Response To Heat Negative Regulation Of Defense Response Killing Of Cells Of Another Organism Negative Regulation Of Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Activation Regulation Of Immune Response Defense Response To Virus
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 31171785 32109421) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Telomere length ( 33941849)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 23817571) Asthma ( 27182965 29273806 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474 29273806) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basophil percentage of white cells ( 27863252) Behcet's disease ( 23001997) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 30072576) Cervical cancer ( 23482656) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Chronic obstructive pulmonary disease ( 30804561) Clozapine-induced agranulocytosis ( 25187353) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cold sores ( 28928442) Cutaneous lupus erythematosus ( 25827949) Eosinophil count ( 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Gastroesophageal reflux disease ( 31527586) Heel bone mineral density ( 30598549) Height ( 20881960) Hepatocellular carcinoma ( 21499248) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 25673412 34021172) HIV-1 control ( 21051598) IgA levels ( 28628107) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Mononucleosis ( 28928442) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-chemotherapy drug induced agranulocytosis ( 27157822) Offspring birth weight ( 31043758) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Perceived unattractiveness to mosquitoes ( 28199695) Platelet distribution width ( 27863252) Pneumonia ( 28928442) Psoriasis ( 23143594) Pubertal anthropometrics ( 23449627) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Self-reported allergy ( 23817569) Takayasu arteritis ( 25604533 23830517 33308445) Tonsillectomy ( 27182965) Trichloroethylene-induced hypersensitivity syndrome ( 26190474) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196)
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	1 interacting genes: POT1
Entrez ID		25913	100507436
HPRD ID		07572
Ensembl ID		ENSG00000128513	ENSG00000204520
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	A0A024RCL3 A0A0G2JJ55 Q29983 Q96QC4
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK	1B3J 1HYR 6DDM 6DDR 6DDV 7FI5 7FI6 7FI7 7FI8 7FI9 8TLZ 8TM0 8TM2
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere Nuclear Telomere Cap Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Regulation Of DNA Strand Elongation Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding RNA-templated DNA Biosynthetic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Chromosome, Telomeric Region Regulation Of DNA Repair Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization Establishment Of Protein Localization To Organelle
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