ARRB1 and NEDD4L

Number of citations of the paper that reports this interaction (PubMedID 25589675)
54

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ARRB1	NEDD4L
Description		arrestin beta 1	NEDD4 like E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Membrane Nuclear Body Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Cell Projection	Nucleoplasm Cytoplasm Endosome Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Molecular Adaptor Activity Arrestin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Sensory Perception Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Protein Transport Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction	Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Monoatomic Ion Transport Neuromuscular Junction Development Protein Ubiquitination Cell Differentiation Neuron Projection Development Receptor Internalization Regulation Of Protein Stability Receptor Catabolic Process Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Regulation Of Membrane Repolarization Regulation Of Biological Quality Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Alanine aminotransferase levels ( 34315874 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874 33547301) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 33339817 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Manganese levels ( 26025379) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817 33547301)
Interacting Genes		58 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CRHR1 CSK CXCR2 CYTH2 DVL1 DVL2 EIF2AK4 FGR FLNA GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEDD4L NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SNCA SREBF2 TIAM1 TP53 TRHR ZBTB43	151 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT1 AKT3 AMOT APEX2 ARHGDIA ARRB1 ARRB2 AURKC BBX BMPR1A CACNB1 CAMK1D CDC34 CDK3 CDK5 CEP55 CHLSN CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 FOXO1 GORAB GRIA1 H1-0 HAX1 HNRNPD HSPA5 IFRD2 IKBKB IL6ST KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP1LC3A MAP2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NEIL3 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 OGG1 PBX1 PDCD6IP PIP4P2 PRKX PRR16 PRRG1 PRRG2 PSMD4 PTGR3 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SLC9A3 SMAD2 SMAD3 SMAD7 SNCA SP1 SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRAF3 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 USP7 VDAC2 WBP2 WNK4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HAV1L ZDHHC3
Entrez ID		408	23327
HPRD ID		00146	05903
Ensembl ID		ENSG00000137486	ENSG00000049759
Uniprot IDs		B7Z1Q3 P49407	A0A1B0GVY1 B7Z2P9 B7Z6K0 Q96PU5
PDB IDs		2IV8 6PWC 6TKO 6UP7 7R0C 7R0J 7SRS 8AS2 8AS3 8AS4 8JRV 8WRZ 9II2 9II3	2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK 6ZBT 6ZC9 7LP1 7LP2 7LP3 7LP4 7LP5 7NMZ
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Transport Regulation Of Signaling Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane Protein Kinase Activity Cytosol Regulation Of Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Protein Phosphorylation Regulation Of Multicellular Organismal Process Endocytosis Positive Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport G Protein-coupled Receptor Activity Regulation Of Cellular Component Organization Phosphorylation Positive Regulation Of Organelle Organization Immune Response-regulating Signaling Pathway Import Into Cell Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Endocytosis Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Receptor Internalization Positive Regulation Of Cell Communication Regulation Of Cytoskeleton Organization MAP Kinase Activity Regulation Of MAPK Cascade Regulation Of Organelle Organization Protein Serine Kinase Activity Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Neuronal Dense Core Vesicle MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Localization	Ubiquitin Conjugating Enzyme Activity Protein Kinase Activity ATP Binding Protein Serine/threonine Kinase Activity Protein Modification Process Ubiquitin Protein Ligase Binding Kinase Activity Nucleotide Binding Protein Serine Kinase Activity Protein Phosphorylation Transferase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Protein Polyubiquitination Protein Metabolic Process Regulation Of Signaling Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cytoplasm Regulation Of Transport Protein Autophosphorylation Cellular Response To Oxygen-containing Compound Protein Domain Specific Binding Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Transmembrane Transporter Binding Protein K11-linked Ubiquitination Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication TORC1 Signaling Protein Sequestering Activity Macromolecule Catabolic Process Nucleus Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Potassium Channel Regulator Activity Regulation Of Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Signal Transduction
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