POT1 and STUB1

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		POT1	STUB1
Description		protection of telomeres 1	STIP1 homology and U-box containing protein 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Protein Folding Chaperone Complex
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity R-SMAD Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	MAPK Cascade Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway ERAD Pathway ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitophagy Positive Regulation Of ERAD Pathway Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 31171785 32109421) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Telomere length ( 33941849)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	149 interacting genes: ABL1 ACD ADRM1 AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BBOX1 BCR BMPR1B CASP6 CCL28 CDK4 CDK9 CDKN1A CFTR CIP2A CRIP1 CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EGFR EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FXR1 GHR GPR37 GUCY1A1 GUCY1A2 HMGB1 HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 HUNK INSR JAK1 JOSD1 JOSD2 KHDRBS1 KPNA2 LRRK1 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 METTL14 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 OTUD3 PA2G4 PFN1 PKM PLK1 PMAIP1 POLB POT1 PPP3CA PRKACA PRKCZ PRKN PRMT1 PSMA3 PSMC2 PSMD1 PSMD2 PSMD4 RAF1 RFFL RGS17 RHBDF2 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SLC7A11-AS1 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNCA SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TP53 TP63 TP73 TPD52 TRAF6 TTN TXN2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W UNC45B VCP VDAC1 XIAP YTHDF2
Entrez ID		25913	10273
HPRD ID		07572	06232
Ensembl ID		ENSG00000128513	ENSG00000103266
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	Q9UNE7
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK	4KBQ 6EFK 6NSV 7TB1 8EHZ 8EI0 8F14 8F15 8F16 8F17 8FYU 8GCK 8SUV 9DRY
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process	Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Intracellular Signal Transduction Cytosol Regulation Of Primary Metabolic Process Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Nucleus Cytoplasm Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleotide Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Cellular Response To Stress Proteasomal Protein Catabolic Process
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