ARRB1 and JUN

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		ARRB1	JUN
Gene Name		arrestin, beta 1	jun proto-oncogene
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle	Nuclear Chromosome Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytosol Transcriptional Repressor Complex
	Molecular Function	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Rho GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding R-SMAD Binding HMG Box Domain Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Angiogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Liver Development Positive Regulation Of Endothelial Cell Proliferation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Aging Learning Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Response To Mechanical Stimulus Monocyte Differentiation Axon Regeneration Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Rho GTPase Activity Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Leading Edge Cell Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Response To Hydrogen Peroxide Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Innate Immune Response Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Potassium Ion Starvation Stress-activated MAPK Cascade Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Pre-NOTCH Transcription and Translation MyD88 dependent cascade initiated on endosome Pre-NOTCH Expression and Processing TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs			Vinblastine Irbesartan Arsenic trioxide
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Cognitive performance ( 19734545)
Protein-Protein Interactions		52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43	185 interactors: ABL1 APLP2 APP AR ARRB1 ASCC1 ASCC2 ASCC3 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BATF3 BBS7 BCL3 BCL6 BRCA1 CASP9 CEBPE CEBPG CLINT1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CREB3 CREB5 CREBBP CSNK2A1 CSNK2A2 CSNK2B DACH1 DDIT3 DDX21 DHX9 EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GOPC GPS1 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFATC2 NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RFWD2 RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBE2I VAV1 VDR
Entrez ID		408	3725
HPRD ID		00146	01302
Ensembl ID		ENSG00000137486	ENSG00000177606
Uniprot IDs		B7Z1Q3 P49407	P05412
PDB IDs		2IV8	1A02 1FOS 1JNM 1JUN 1S9K 1T2K
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Cellular Response To Stress Cell Differentiation Multicellular Organismal Development Response To Organic Substance Anatomical Structure Development Response To Stress Organ Development Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance System Development DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield
Tagcloud (Difference) ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield
Tagcloud (Intersection) ?