ARRB1 and PTH1R

Number of citations of the paper that reports this interaction (PubMedID 12220636)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARRB1	PTH1R
Description		arrestin beta 1	parathyroid hormone 1 receptor
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Membrane Nuclear Body Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Cell Projection	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Molecular Adaptor Activity Arrestin Family Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Sensory Perception Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Protein Transport Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction	Skeletal System Development Ossification In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			Abaloparatide Parathyroid hormone Teriparatide
Diseases			Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Birth weight ( 27680694 31043758) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		58 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CRHR1 CSK CXCR2 CYTH2 DVL1 DVL2 EIF2AK4 FGR FLNA GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEDD4L NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SNCA SREBF2 TIAM1 TP53 TRHR ZBTB43	16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 NHERF1 NHERF2 PTH PTHLH SMARCC1 STK16 TEKT4 UBC YWHAH
Entrez ID		408	5745
HPRD ID		00146	01347
Ensembl ID		ENSG00000137486	ENSG00000160801
Uniprot IDs		B7Z1Q3 P49407	Q03431 Q0VGD7
PDB IDs		2IV8 6PWC 6TKO 6UP7 7R0C 7R0J 7SRS 8AS2 8AS3 8AS4 8JRV 8WRZ 9II2 9II3	1BL1 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI 7UZO 7UZP 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7Y35 7Y36 8BIA 8BJ0 8D51 8D52 8FLQ 8FLR 8FLS 8FLT 8FLU 8GW8 8HA0 8HAF 8HAO 8JR9 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Transport Regulation Of Signaling Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane Protein Kinase Activity Cytosol Regulation Of Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Protein Phosphorylation Regulation Of Multicellular Organismal Process Endocytosis Positive Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport G Protein-coupled Receptor Activity Regulation Of Cellular Component Organization Phosphorylation Positive Regulation Of Organelle Organization Immune Response-regulating Signaling Pathway Import Into Cell Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Endocytosis Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Receptor Internalization Positive Regulation Of Cell Communication Regulation Of Cytoskeleton Organization MAP Kinase Activity Regulation Of MAPK Cascade Regulation Of Organelle Organization Protein Serine Kinase Activity Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Neuronal Dense Core Vesicle MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Localization	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Hormone Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Phosphate Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Cartilage Development Protein-membrane Adaptor Activity Sensory Perception Molecular Adaptor Activity Semicircular Canal Formation Cyclic Purine Nucleotide Metabolic Process Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Glucocorticoid Catabolic Process Renal Phosphate Ion Absorption Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Regulation Of Chondrocyte Differentiation Phosphatase Binding Bone Mineralization Angiotensin Receptor Binding Abducens Nerve Formation Optokinetic Behavior Regulation Of Sodium Ion Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding
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