POT1 and ACOT7

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		POT1	ACOT7
Name		protection of telomeres 1	acyl-CoA thioesterase 7
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	Fatty-acyl-CoA Binding Protein Binding Hydrolase Activity Thiolester Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Protein Homodimerization Activity Fatty Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Catabolic Process Coenzyme A Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Medium-chain Fatty Acid Biosynthetic Process Palmitic Acid Biosynthetic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Mitochondrial Fatty Acid Beta-Oxidation
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464 ) Cutaneous malignant melanoma ( 26237428 ) Leukocyte telomere length ( 31171785 32109421 ) Refractive error ( 32231278 ) Response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Telomere length ( 33941849 )	A body shape index ( 34021172 ) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902 ) HDL cholesterol levels in HIV infection ( 33109212 ) Metabolite levels ( 31628463 ) QT interval ( 19305408 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 )
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	26 interacting genes: ACOT12 ATXN1 ATXN1L BAG4 CAMK2B CDC42 CRYAB DAZAP2 DLC1 ENKD1 FXR1 HOXA1 LMNA MAGEA3 MAGEA6 NCOA5 POT1 POU6F1 SPATC1L TERF1 THAP1 TINF2 UBQLN1 UBQLN2 UBXN1 ZNF438
Entrez ID		25913	11332
HPRD ID		07572	12517
Ensembl ID		ENSG00000128513	ENSG00000097021
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	O00154
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK	2QQ2
GO Terms Enriched among Interactors		Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Shelterin Complex Negative Regulation Of Metabolic Process Nuclear Telomere Cap Complex Identical Protein Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Telomere Capping Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Component Organization Nucleus Regulation Of ERAD Pathway Telomeric DNA Binding Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Telomere Maintenance Via Telomere Lengthening POZ Domain Binding Negative Regulation Of DNA Biosynthetic Process Telomere Assembly Regulation Of Metabolic Process Nuclear Pore Localization Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Polyubiquitin Modification-dependent Protein Binding Muscle Organ Development Regulation Of Telomere Maintenance Via Telomerase Muscle Structure Development Negative Regulation Of DNA-templated Transcription Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of RNA Biosynthetic Process Cellular Component Assembly Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Organelle Organization Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of ERAD Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Stress Fiber Assembly Regulation Of Chromosome Organization Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Telomere Maintenance Via Telomerase