ARRB1 and ZBTB43

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARRB1	ZBTB43
Gene Name		arrestin, beta 1	zinc finger and BTB domain containing 43
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle	Nucleus
	Molecular Function	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding	DNA Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43	19 interactors: AEN AP1M1 ARR3 ARRB1 BDP1 DIP2A FAM161A LMO1 LMO3 LMO4 LNX1 MCM10 MORF4L2 PSMD3 SYT6 TCEB3B TRAF2 ZBTB24 ZNF417
Entrez ID		408	23099
HPRD ID		00146	08346
Ensembl ID		ENSG00000137486	ENSG00000169155
Uniprot IDs		B7Z1Q3 P49407	O43298
PDB IDs		2IV8	2CSH
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Metabolic Process Protein Ubiquitination Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Binding Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Post-Golgi Vesicle-mediated Transport Acrosomal Vesicle Exocytosis Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Binding
Tagcloud ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates
Tagcloud (Difference) ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates
Tagcloud (Intersection) ?