POT1 and APPL2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		POT1	APPL2
Gene Name		protection of telomeres 1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Endosome Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding	Protein Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation	Cell Cycle Signal Transduction Cell Proliferation
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	11 interactors: APPL1 CRADD MTA2 POT1 RAB22A RAB5A RAB5C RBBP7 RUVBL2 SUV39H2 TINF2
Entrez ID		25913	55198
HPRD ID		07572	06945
Ensembl ID		ENSG00000128513	ENSG00000136044
Uniprot IDs		A8MTK3 Q5MJ33 Q9NUX5	Q8NEU8
PDB IDs		1XJV 3KJO 3KJP	4H8S
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process	Chromatin Remodeling Chromosome Organization Rab Protein Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Chromatin Assembly Or Disassembly DNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Chromatin Modification Ras Protein Signal Transduction Organelle Organization Negative Regulation Of Biosynthetic Process Cellular Protein Localization Negative Regulation Of DNA Replication Chromatin Organization DNA Conformation Change Telomere Maintenance ATP-dependent Chromatin Remodeling Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Regulation Of Cellular Process DNA Duplex Unwinding DNA Geometric Change Histone Modification Positive Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation Regulation Of Vesicle Size Cellular Heat Acclimation Protein Localization Response To Abiotic Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Telomere Formation Via Telomerase Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Negative Regulation Of Protein Glycosylation Positive Regulation Of DNA Metabolic Process Histone H3-K9 Dimethylation Small GTPase Mediated Signal Transduction
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake
Tagcloud (Difference) ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip	adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake
Tagcloud (Intersection) ?