IRS4 and MTNR1A

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo)

		IRS4	MTNR1A
Description		insulin receptor substrate 4	melatonin receptor 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm
Pathways		IRS-related events triggered by IGF1R	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS			Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)
Interacting Genes		24 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MAP1LC3A MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG	160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460
Entrez ID		8471	4543
HPRD ID		04620	02812
Ensembl ID		ENSG00000133124	ENSG00000168412
Uniprot IDs		A0A804CF45 O14654	P48039
PDB IDs			6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Insulin Receptor Substrate Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of MAPK Cascade Positive Regulation Of Signaling Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Modification Process ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Protein Localization To Membrane Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Regulation Of Protein Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Carbohydrate Homeostasis Glucose Homeostasis Phosphorylation-dependent Protein Binding Regulation Of Cell Migration Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Regulation Of Immune System Process Negative Regulation Of Immune System Process Postsynaptic Specialization Assembly Regulation Of Cell Motility Reelin-mediated Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Locomotion Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process	Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity
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