IRS4 and CSNK1G2

Number of citations of the paper that reports this interaction (PubMedID 30026872)
46

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		IRS4	CSNK1G2
Description		insulin receptor substrate 4	casein kinase 1 gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Sphingolipid Biosynthetic Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		IRS-related events triggered by IGF1R	Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs			IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS			Body mass index ( 25673413) Coronary artery disease ( 29212778) Periodontitis (stage III/IV grade C) ( 33745150) Red cell distribution width ( 27863252 32888494) Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		24 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MAP1LC3A MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG	17 interacting genes: APP APPBP2 CERT1 CLSPN DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 OGT PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 SNCA WDCP
Entrez ID		8471	1455
HPRD ID		04620	03738
Ensembl ID		ENSG00000133124	ENSG00000133275
Uniprot IDs		A0A804CF45 O14654	P78368
PDB IDs			2C47
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Insulin Receptor Substrate Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of MAPK Cascade Positive Regulation Of Signaling Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Modification Process ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Protein Localization To Membrane Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Regulation Of Protein Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Carbohydrate Homeostasis Glucose Homeostasis Phosphorylation-dependent Protein Binding Regulation Of Cell Migration Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Regulation Of Immune System Process Negative Regulation Of Immune System Process Postsynaptic Specialization Assembly Regulation Of Cell Motility Reelin-mediated Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Locomotion Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process	Regulation Of Cell Junction Assembly Regulation Of Phosphorus Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Presynapse Organization Insulin Receptor Binding Chemical Homeostasis Negative Regulation Of RNA Biosynthetic Process Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Ephrin Receptor Binding Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process Regulation Of Presynapse Assembly Negative Regulation Of DNA-templated Transcription Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Copper Ion Chromatin DNA Binding Negative Regulation Of Protein Catabolic Process Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Circadian Rhythm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microglial Cell Activation Regulation Of Protein Catabolic Process Regulation Of Supramolecular Fiber Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of Synapse Assembly Response To Copper Ion Positive Regulation Of Endocytosis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Locomotory Behavior Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein Kinase Inhibitor Activity
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