IRS4 and MAGEL2

Number of citations of the paper that reports this interaction (PubMedID 28973533)
77

Data Source:
BioGRID (two hybrid)

		IRS4	MAGEL2
Description		insulin receptor substrate 4	MAGE family member L2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Endosome Early Endosome Cytosol Retromer Complex
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Actin Nucleation Protein K63-linked Ubiquitination
Pathways		IRS-related events triggered by IGF1R
Drugs
Diseases
GWAS			Menarche (age at onset) ( 25231870) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		24 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MAP1LC3A MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG	6 interacting genes: FHL2 IRS4 PCGF6 RNF41 SUFU VPS52
Entrez ID		8471	54551
HPRD ID		04620	12008
Ensembl ID		ENSG00000133124	ENSG00000254585
Uniprot IDs		A0A804CF45 O14654	Q9UJ55
PDB IDs
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Insulin Receptor Substrate Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of MAPK Cascade Positive Regulation Of Signaling Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Modification Process ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Protein Localization To Membrane Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Regulation Of Protein Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Carbohydrate Homeostasis Glucose Homeostasis Phosphorylation-dependent Protein Binding Regulation Of Cell Migration Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Regulation Of Immune System Process Negative Regulation Of Immune System Process Postsynaptic Specialization Assembly Regulation Of Cell Motility Reelin-mediated Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Locomotion Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process	Atrial Cardiac Muscle Cell Development Embryonic Ectodermal Digestive Tract Development Interleukin-3 Receptor Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Positive Regulation Of Response To Drug Erythropoietin Receptor Binding Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification GARP Complex EARP Complex Ectodermal Cell Differentiation GLI-SUFU Complex Transcription Corepressor Activity Vesicle-mediated Cholesterol Transport Regulation Of Response To Drug Spinal Cord Dorsal/ventral Patterning
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