IRS4

Description		insulin receptor substrate 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway
Pathways		IRS-related events triggered by IGF1R
Drugs
Diseases
GWAS
Interacting Genes		24 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MAP1LC3A MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		8471
HPRD ID		04620
Ensembl ID		ENSG00000133124
Uniprot IDs		A0A804CF45 O14654
PDB IDs
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Insulin Receptor Substrate Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of MAPK Cascade Positive Regulation Of Signaling Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Modification Process ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Protein Localization To Membrane Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Regulation Of Protein Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Carbohydrate Homeostasis Glucose Homeostasis Phosphorylation-dependent Protein Binding Regulation Of Cell Migration Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Regulation Of Immune System Process Negative Regulation Of Immune System Process Postsynaptic Specialization Assembly Regulation Of Cell Motility Reelin-mediated Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Locomotion Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process
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