IRS4 and NISCH

Number of citations of the paper that reports this interaction (PMID 11912194)
7

Data Source:
HPRD (in vivo)

		IRS4	NISCH
Gene Name		insulin receptor substrate 4	nischarin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Early Endosome Cytosol Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Integrin Binding Protein Binding G-protein Coupled Amine Receptor Activity Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process	Glucose Metabolic Process Apoptotic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion
Pathways		IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		17 interactors: CRK CRKL EGFR ERBB2 GRB2 IGF1R MTNR1A MTNR1B NISCH PIK3CA PIK3R1 PRKCZ PTPN11 PTPN6 SOCS6 SOCS7 YWHAG	3 interactors: AR IRS4 ITGA5
Entrez ID		8471	11188
HPRD ID		04620	11391
Ensembl ID		ENSG00000133124	ENSG00000010322
Uniprot IDs		O14654	Q9Y2I1
PDB IDs			3P0C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Cellular Response To Insulin Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Insulin Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Regulation Of Protein Kinase Activity Response To Organonitrogen Compound Response To Hormone Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Signaling Regulation Of T Cell Activation Signal Transduction Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of Lymphocyte Activation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Activation Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process T Cell Costimulation Regulation Of Immune Response	Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase III Promoter Wound Healing, Spreading Of Epidermal Cells Cell Adhesion Mediated By Integrin Regulation Of Signal Transduction Cellular Response To Hormone Stimulus Negative Regulation Of Anoikis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anoikis Regulation Of Signaling Heterotypic Cell-cell Adhesion Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Phosphorylation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Androgen Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Hormone Endodermal Cell Differentiation Wound Healing, Spreading Of Cells Negative Regulation Of Cell Death Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell-substrate Junction Assembly Regulation Of Protein Localization To Plasma Membrane Endoderm Formation Morphogenesis Of An Epithelial Sheet
Tagcloud ?		arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2	23b 27b antitumor augmented biologic cascade correlates delivered engineered erbb2 feedback intraperitoneally inversely mir mirnas neu noncoding notably nucleotides relevance repressed restored rnas substantially suppress suppressing underscoring xenograft
Tagcloud (Difference) ?		arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2	23b 27b antitumor augmented biologic cascade correlates delivered engineered erbb2 feedback intraperitoneally inversely mir mirnas neu noncoding notably nucleotides relevance repressed restored rnas substantially suppress suppressing underscoring xenograft
Tagcloud (Intersection) ?