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IRS4 and NISCH
Number of citations of the paper that reports this interaction (PubMedID
11912194
)
0
Data Source:
HPRD
(in vivo)
IRS4
NISCH
Description
insulin receptor substrate 4
nischarin
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Membrane
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Intercellular Bridge
Recycling Endosome
Molecular Function
Insulin Receptor Binding
Protein Binding
Phosphatidylinositol 3-kinase Binding
Integrin Binding
Protein Binding
Phosphatidylinositol Binding
Identical Protein Binding
Biological Process
Signal Transduction
Insulin Receptor Signaling Pathway
Apoptotic Process
Rac Protein Signal Transduction
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Pathways
IRS-related events triggered by IGF1R
RAC1 GTPase cycle
RND3 GTPase cycle
RND2 GTPase cycle
Drugs
Tizanidine
Agmatine
Moxonidine
Tepotinib
Diseases
GWAS
A body shape index (
34021172
)
Apolipoprotein B levels (
32203549
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
31043756
)
Colon cancer (
33632709
)
Distal colorectal cancer (
33632709
)
General cognitive ability (
29844566
)
HDL cholesterol levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Parkinson's disease (
28892059
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (
29483656
25056061
23974872
)
Triglyceride levels (
32203549
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-hip ratio (
20935629
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
24 interacting genes:
CRK
CRKL
CSNK1G2
EGFR
ERBB2
GRB2
IGF1R
MAGEL2
MAP1LC3A
MTNR1A
MTNR1B
NDN
NISCH
OGT
PIK3CA
PIK3R1
PRKCZ
PTEN
PTPN11
PTPN6
RNF41
SOCS6
SOCS7
YWHAG
10 interacting genes:
AR
BTG3
CLIC6
IRS4
ITGA5
KLHL20
OGT
PTGER4
VHL
WEE2-AS1
Entrez ID
8471
11188
HPRD ID
04620
11391
Ensembl ID
ENSG00000133124
ENSG00000010322
Uniprot IDs
A0A804CF45
O14654
C9J715
Q9Y2I1
PDB IDs
3P0C
8ESF
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Intracellular Signal Transduction
Insulin Receptor Substrate Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of Signal Transduction
Receptor Tyrosine Kinase Binding
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Regulation Of Signaling
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway
Intracellular Signaling Cassette
Regulation Of MAPK Cascade
Positive Regulation Of Signaling
Cytosol
Epidermal Growth Factor Receptor Signaling Pathway
Protein Modification Process
ERBB Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Protein Localization To Membrane
Positive Regulation Of Protein Localization To Membrane
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Cell Adhesion
Regulation Of Protein Localization
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Cell Adhesion
Carbohydrate Homeostasis
Glucose Homeostasis
Phosphorylation-dependent Protein Binding
Regulation Of Cell Migration
Regulation Of Lymphocyte Activation
Regulation Of Cellular Localization
Regulation Of Immune System Process
Negative Regulation Of Immune System Process
Postsynaptic Specialization Assembly
Regulation Of Cell Motility
Reelin-mediated Signaling Pathway
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Locomotion
Regulation Of T Cell Activation
Regulation Of Multicellular Organismal Process
Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
Prostate Induction
Regulation Of Programmed Cell Death
Male Genitalia Morphogenesis
POU Domain Binding
Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Male Somatic Sex Determination
Positive Regulation Of Integrin Biosynthetic Process
Integrin Alpha5-beta1 Complex
Alphav-beta3 Integrin-vitronectin Complex
Negative Regulation Of Eosinophil Extravasation
Negative Regulation Of Integrin Activation
Negative Regulation Of Eosinophil Migration
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein-containing Complex Assembly
Prostaglandin Receptor Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Regulation Of TORC1 Signaling
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Protein O-acetylglucosaminyltransferase Activity
Protein K33-linked Ubiquitination
Type II Interferon Binding
D2 Dopamine Receptor Binding
D4 Dopamine Receptor Binding
D3 Dopamine Receptor Binding
Pre-mRNA 5'-splice Site Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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