DYRK3 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		DYRK3	FBXO25
Description		dual specificity tyrosine phosphorylation regulated kinase 3	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Stress Granule Nuclear Speck	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Protein Phosphorylation Erythrocyte Differentiation Nuclear Speck Organization Stress Granule Disassembly Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Division Regulation Of Cellular Response To Stress Positive Regulation Of Cell Cycle G2/M Phase Transition Organelle Disassembly Regulation Of TORC1 Signaling	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		12 interacting genes: ACAA2 ADAM22 DNAJA2 DNAJB1 FBXO25 GORASP2 MAGI2 NEDD4L PGM1 PRNP SNAPIN ZNF350	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		8444	26260
HPRD ID		04607	16439
Ensembl ID		ENSG00000143479	ENSG00000147364
Uniprot IDs		O43781	Q8TCJ0
PDB IDs		5Y86
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
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