DYRK3 and ACAA2

Number of citations of the paper that reports this interaction (PubMedID 36585413)
42

Data Source:
BioGRID (two hybrid)

		DYRK3	ACAA2
Description		dual specificity tyrosine phosphorylation regulated kinase 3	acetyl-CoA acyltransferase 2
Image
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Stress Granule Nuclear Speck	Mitochondrion Mitochondrial Matrix Nuclear Body Ciliary Basal Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA Hydrolase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Protein Phosphorylation Erythrocyte Differentiation Nuclear Speck Organization Stress Granule Disassembly Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Division Regulation Of Cellular Response To Stress Positive Regulation Of Cell Cycle G2/M Phase Transition Organelle Disassembly Regulation Of TORC1 Signaling	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Cholesterol Biosynthetic Process Cellular Response To Hypoxia Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways			Mitochondrial Fatty Acid Beta-Oxidation
Drugs			Trimetazidine
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Apolipoprotein A1 levels ( 29084231) Cerebrospinal fluid immune biomarker levels ( 32066700) Cholesterol ester levels in very large HDL ( 29084231) Free cholesterol levels in medium HDL ( 29084231) HDL cholesterol ( 18193044) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heschl's gyrus morphology ( 25130324) Large HDL particle concentration ( 29084231) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		12 interacting genes: ACAA2 ADAM22 DNAJA2 DNAJB1 FBXO25 GORASP2 MAGI2 NEDD4L PGM1 PRNP SNAPIN ZNF350	7 interacting genes: APP DYRK3 HSPB2 LAMTOR5 SCP2 SNRPA TERT
Entrez ID		8444	10449
HPRD ID		04607	10380
Ensembl ID		ENSG00000143479	ENSG00000167315
Uniprot IDs		O43781	B3KNP8 P42765
PDB IDs		5Y86	4C2J 4C2K
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lipid Hydroperoxide Transport Oleic Acid Binding Acetyl-CoA C-myristoyltransferase Activity Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Hair Cycle Positive Regulation Of Protein Localization To Nucleus RNA-directed DNA Polymerase Activity Telomerase Catalytic Core Complex Regulation Of TORC1 Signaling Detection Of Nodal Flow Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine
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