RUFY1 and ITSN2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid)

		RUFY1	ITSN2
Description		RUN and FYVE domain containing 1	intersectin 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Centrosome Cytosol Plasma Membrane Presynaptic Membrane Extracellular Exosome Intracellular Vesicle
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport	Endocytosis Endosomal Transport Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		Synthesis of PIPs at the plasma membrane	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)	Appendicular lean mass ( 33097823) Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Sjögren's syndrome ( 24097067) Total cholesterol levels ( 33339817)
Interacting Genes		20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25	74 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SNCA SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		80230	50618
HPRD ID		15282	09193
Ensembl ID		ENSG00000176783	ENSG00000198399
Uniprot IDs		A8K7B1 Q96T51	A6H8W8 Q9NZM3
PDB IDs		2YQM 2YW8	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement	SH3 Domain Binding Endocytosis Cell Projection Vesicle-mediated Transport Actin Filament-based Movement Import Into Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cytoplasm Synaptic Vesicle Endocytosis Organelle Localization Glutamatergic Synapse Presynaptic Endocytosis Actin Binding Vesicle-mediated Transport In Synapse Organelle Organization Supramolecular Fiber Organization Cadherin Binding Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cellular Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Membrane Organization MRNA Binding Protein Complex Oligomerization Regulation Of Vesicle-mediated Transport Regulation Of Angiotensin-activated Signaling Pathway Intracellular Transport Apical Constriction Positive Regulation Of RNA Export From Nucleus Cellular Component Assembly Cytosol Actin Cytoskeleton Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cell-cell Signaling Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission
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