RUFY1 and AP3M1

Number of citations of the paper that reports this interaction (PubMedID 23144738)
65

Data Source:
BioGRID (pull down)

		RUFY1	AP3M1
Description		RUN and FYVE domain containing 1	adaptor related protein complex 3 subunit mu 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Lysosome Lysosomal Membrane Early Endosome Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Recycling Endosome Axon Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding	Protein Binding Small GTPase Binding
	Biological Process	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport	Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Postsynaptic Neurotransmitter Receptor Internalization Melanosome Assembly
Pathways		Synthesis of PIPs at the plasma membrane	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)	Cardiac troponin-I levels ( 31014085) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25	14 interacting genes: AGTRAP AQP4 ARNT2 CRMP1 DVL3 IL36RN RUFY1 SIPA1L2 SLC12A4 SPAG16 TGOLN2 TRIM14 TRIM23 TRIM9
Entrez ID		80230	26985
HPRD ID		15282	16496
Ensembl ID		ENSG00000176783	ENSG00000185009
Uniprot IDs		A8K7B1 Q96T51	B4DRN6 Q9Y2T2
PDB IDs		2YQM 2YW8	9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement	Cerebrospinal Fluid Circulation
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