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ITSN2 and ITSN1
Number of citations of the paper that reports this interaction (PubMedID
22558309
)
58
Data Source:
BioGRID
(protein complementation assay)
ITSN2
ITSN1
Description
intersectin 2
intersectin 1
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Presynaptic Membrane
Extracellular Exosome
Intracellular Vesicle
Nucleus
Nuclear Envelope
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Endomembrane System
Membrane
Lamellipodium
Cytoplasmic Vesicle
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Synapse
Recycling Endosome
Apical Dendrite
Intracellular Vesicle
Postsynaptic Endocytic Zone
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Molecular Adaptor Activity
Proline-rich Region Binding
Biological Process
Endocytosis
Endosomal Transport
Cell Differentiation
Clathrin-dependent Synaptic Vesicle Endocytosis
Positive Regulation Of Dendrite Extension
Exocytosis
Endocytosis
Intracellular Protein Localization
Regulation Of Cell Communication
Protein Transport
Endosomal Transport
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Growth Hormone Secretion
Positive Regulation Of Dendritic Spine Development
Regulation Of Postsynapse Organization
Clathrin-dependent Synaptic Vesicle Endocytosis
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Positive Regulation Of Caveolin-mediated Endocytosis
Pathways
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
RHOU GTPase cycle
NRAGE signals death through JNK
EPHB-mediated forward signaling
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
CDC42 GTPase cycle
RHOQ GTPase cycle
RHOG GTPase cycle
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Asthma (
29273806
)
Chromium levels (
26025379
)
Diffuse large B cell lymphoma (
25261932
)
Feeling fed-up (
29500382
)
Low density lipoprotein cholesterol levels (
32154731
33339817
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Response to antipsychotic treatment in schizophrenia (working memory) (
21107309
)
Sjögren's syndrome (
24097067
)
Total cholesterol levels (
33339817
)
Bitter non-alcoholic beverage consumption (
31046077
)
Educational attainment (
25201988
)
Height (
31562340
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
QT interval (
29213071
)
Red blood cell count (
32888494
)
Red cell distribution width (
27863252
32888494
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
74 interacting genes:
AGT
AHDC1
AMPH
ANKRD17
BCCIP
CBL
CCDC88C
CHIC2
CPSF6
DLGAP1
DST
EGFR
EPS8
ERC1
FASLG
FCHSD1
FCHSD2
FNBP4
GAREM2
GOLGA2
GOLGA8A
GOLGB1
GPNMB
HNRNPK
HOOK2
ITPKA
ITSN1
KCTD10
KDM1A
KHDRBS1
KIAA1549
KXD1
LSM8
LTBP4
LUC7L3
MAP4K3
MBNL1
MEGF10
NBR1
NR2C2
PDCD6IP
PDE4DIP
PIK3AP1
PIK3C2B
PSEN1
PTN
RAD9A
RBMX
REPS1
RNF20
ROCK1
RUFY1
SEMA6A
SH3GL1
SH3KBP1
SNAP29
SNCA
SOS1
SOS2
STX4
SYN1
SYNJ2
TACC1
TBL3
TMF1
TRIO
UBC
WAS
WASF2
WASL
WIPF1
WIPF2
YLPM1
YTHDF1
140 interacting genes:
AGFG1
AGFG2
AJUBA
ANKRD36
ANKRD54
ARF6
ARFIP2
ARHGAP31
ASAP2
BECN1
BFSP1
BRCC3
BRWD3
CCDC24
CCNO
CDC42
CEP85L
CLIP2
CLTC
COG4
CSNK2B
CYTH1
CYTH3
DAB1
DAB2
DES
DISC1
DLGAP1
DNAI7
DNAJA2
DNM1
DNM2
DST
DYNC1H1
EEF1A1
EPHB2
EPN2
EPS15
EXOC1
FCHO1
FCHO2
FCHSD2
FNBP1
FNBP4
GAREM2
GCC1
GFAP
GNPTG
GOLGA5
HIP1
HNRNPK
HRAS
IFT74
ITSN2
KHDRBS1
KIF16B
KIF5A
KIF5C
KRT222
LMO3
LMO4
MAP3K20
MAPK6
MAPK8IP2
MED4
MRPL20
MTUS2
MYH14
NASP
NEFL
NEFM
NEMF
PACSIN3
PDCD6IP
PDE2A
PDZD8
PFDN5
PICALM
PIK3AP1
PIK3C2B
PIK3R1
PLK1
PPFIA2
PPL
PREX1
PRRG4
RAB11FIP2
RAB5A
RABEP1
RAI14
RALBP1
REPS1
REPS2
RIN1
RNF40
RPS6KA5
RRBP1
SCAI
SCAMP1
SCOC
SF3B4
SH3GL2
SHANK3
SIAH1
SMARCC2
SMC1A
SNAP23
SNAP25
SNRNP70
SNX5
SNX6
SOS1
SOS2
SPDL1
SPECC1
SPRY2
SPTAN1
SPTBN1
STON2
SYNC
SYNE1
SYNJ1
SYNJ2
TK1
TRAF3IP1
TRIM5
TRIM8
TRPM7
TSG101
TTC27
UBC
UBE2K
UNC119
VLDLR
WASL
WBP11
WHAMM
ZFC3H1
ZFPM2
ZMYM5
Entrez ID
50618
6453
HPRD ID
09193
03898
Ensembl ID
ENSG00000198399
ENSG00000205726
Uniprot IDs
A6H8W8
Q9NZM3
A7XZY7
F8W7U0
Q15811
Q6PD56
PDB IDs
1J3T
1UDL
1UE9
1UFF
1UHF
3GF9
3JZY
4IIO
1KI1
2KGR
2KHN
3FIA
3QBV
4IIM
5HZI
5HZJ
5HZK
6GBU
6H5T
Enriched GO Terms of Interacting Partners
?
SH3 Domain Binding
Endocytosis
Cell Projection
Vesicle-mediated Transport
Actin Filament-based Movement
Import Into Cell
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Establishment Of Localization In Cell
Cytoskeleton
Positive Regulation Of Cellular Component Organization
Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of ERBB Signaling Pathway
Cytoplasmic Vesicle
Cytoskeleton Organization
Small GTPase-mediated Signal Transduction
Cytoplasm
Synaptic Vesicle Endocytosis
Organelle Localization
Glutamatergic Synapse
Presynaptic Endocytosis
Actin Binding
Vesicle-mediated Transport In Synapse
Organelle Organization
Supramolecular Fiber Organization
Cadherin Binding
Actin Filament-based Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Localization
Regulation Of Cellular Component Organization
Regulation Of Cytoskeleton Organization
Membrane Organization
MRNA Binding
Protein Complex Oligomerization
Regulation Of Vesicle-mediated Transport
Regulation Of Angiotensin-activated Signaling Pathway
Intracellular Transport
Apical Constriction
Positive Regulation Of RNA Export From Nucleus
Cellular Component Assembly
Cytosol
Actin Cytoskeleton
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Cell-cell Signaling
Regulation Of Intracellular Signal Transduction
Modulation Of Chemical Synaptic Transmission
Endocytosis
Vesicle-mediated Transport
Import Into Cell
Cytoplasm
Cytosol
Establishment Of Localization In Cell
Clathrin-coated Pit
Clathrin Coat Assembly
Cytoskeleton Organization
Organelle Organization
Cytoskeleton
Regulation Of Cellular Component Organization
Receptor-mediated Endocytosis
Organelle Localization
Membrane Organization
Cellular Component Assembly
Clathrin-coated Vesicle
Protein Transport
Clathrin-dependent Endocytosis
Intermediate Filament-based Process
Cellular Localization
Establishment Of Organelle Localization
Intracellular Transport
Negative Regulation Of Cellular Component Organization
Synaptic Vesicle Endocytosis
Establishment Of Protein Localization
Regulation Of Protein Localization To Cell Periphery
Presynaptic Endocytosis
Vesicle-mediated Transport In Synapse
Intermediate Filament Cytoskeleton Organization
Intracellular Protein Localization
Protein-containing Complex Assembly
Clathrin Coat Of Coated Pit
Intermediate Filament Cytoskeleton
Protein-containing Complex Organization
Structural Constituent Of Cytoskeleton
Post-Golgi Vesicle-mediated Transport
Glutamatergic Synapse
Microtubule Binding
Establishment Of Vesicle Localization
Endosomal Transport
Cell Cortex
Cytoplasmic Vesicle
Golgi Vesicle Transport
Regulation Of Protein Localization To Plasma Membrane
Vesicle Localization
Cytoskeleton-dependent Intracellular Transport
Cell Projection Organization
Mitotic Cytokinesis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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