RUFY1 and RAB39B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RUFY1	RAB39B
Description		RUN and FYVE domain containing 1	RAB39B, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle	Autophagosome Membrane Lysosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Neuron Projection Autolysosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport	Autophagy Regulation Of Autophagy Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Synapse Organization
Pathways		Synthesis of PIPs at the plasma membrane	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)
Interacting Genes		20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25	6 interacting genes: GOLGA2 RAB3GAP1 RUFY1 SGSM3 VPS26C ZDHHC17
Entrez ID		80230	116442
HPRD ID		15282	06703
Ensembl ID		ENSG00000176783	ENSG00000155961
Uniprot IDs		A8K7B1 Q96T51	Q96DA2
PDB IDs		2YQM 2YW8	6S5F
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement	Establishment Of Protein Localization Cellular Localization Endosomal Transport Small GTPase-mediated Signal Transduction Cis-Golgi Network Protein Transport Vesicle-mediated Transport Intracellular Transport Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of GTPase Activity Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Hydrolase Activity Regulation Of Vesicle-mediated Transport Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Establishment Of Localization In Cell Regulation Of GTPase Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Glycosylation Intracellular Protein Localization Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Rab Protein Signal Transduction Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Protein Metabolic Process Golgi Disassembly Protein-cysteine S-stearoyltransferase Activity Intracellular Signaling Cassette Regulation Of Protein Glycosylation Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Importin-alpha Family Protein Binding Regulation Of Organelle Assembly GTPase Activator Activity Golgi Ribbon Formation Rap Protein Signal Transduction Plasma Membrane To Endosome Transport Golgi Cis Cisterna Golgi Vesicle Transport Small GTPase Binding Positive Regulation Of Glutamate Secretion Regulation Of Neurotrophin TRK Receptor Signaling Pathway Asymmetric Cell Division Positive Regulation Of Catalytic Activity Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity
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