ITSN2 and PIK3C2B

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN2	PIK3C2B
Gene Name		intersectin 2	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Nucleus Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Endocytic Vesicle
	Molecular Function	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Biological_process Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling
Pathways			Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Working memory ( 21107309)	Breast cancer ( 23535733) Prostate cancer ( 23535732)
Protein-Protein Interactions		75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	9 interactors: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 YWHAQ
Entrez ID		50618	5287
HPRD ID		09193	04160
Ensembl ID		ENSG00000198399	ENSG00000133056
Uniprot IDs		A6H8W8 Q9NZM3	A2RUF7 F5GWN5 O00750
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Chemotaxis Regulation Of MAPK Cascade Locomotion Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Phosphorylation System Development Regulation Of Immune Response Axon Guidance Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Multicellular Organismal Development Cell Surface Receptor Signaling Pathway
Tagcloud ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Difference) ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Intersection) ?