ITSN2 and PIK3C2B

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid)

		ITSN2	PIK3C2B
Description		intersectin 2	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Presynaptic Membrane Extracellular Exosome Intracellular Vesicle	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Endocytic Vesicle Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Nucleotide Binding Lipid Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Endocytosis Endosomal Transport Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension	Lipid Metabolic Process Cellular Response To Starvation Macroautophagy Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Autophagosome Organization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle	Synthesis of PIPs at the plasma membrane
Drugs			Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Sjögren's syndrome ( 24097067) Total cholesterol levels ( 33339817)	Breast cancer ( 23535733) Facial morphology ( 29921221) FEV1 ( 30804560) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30804560) Oily fish consumption ( 32066663) Peak expiratory flow ( 30804560) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889)
Interacting Genes		74 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SNCA SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	9 interacting genes: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 UBC
Entrez ID		50618	5287
HPRD ID		09193	04160
Ensembl ID		ENSG00000198399	ENSG00000133056
Uniprot IDs		A6H8W8 Q9NZM3	A2RUF7 F5GWN5 O00750
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Endocytosis Cell Projection Vesicle-mediated Transport Actin Filament-based Movement Import Into Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cytoplasm Synaptic Vesicle Endocytosis Organelle Localization Glutamatergic Synapse Presynaptic Endocytosis Actin Binding Vesicle-mediated Transport In Synapse Organelle Organization Supramolecular Fiber Organization Cadherin Binding Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cellular Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Membrane Organization MRNA Binding Protein Complex Oligomerization Regulation Of Vesicle-mediated Transport Regulation Of Angiotensin-activated Signaling Pathway Intracellular Transport Apical Constriction Positive Regulation Of RNA Export From Nucleus Cellular Component Assembly Cytosol Actin Cytoskeleton Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cell-cell Signaling Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission	Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Vesicle Enzyme-linked Receptor Protein Signaling Pathway Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding Receptor Complex Peptidyl-tyrosine Phosphorylation Neurotrophin TRKA Receptor Binding Plasma Membrane ERBB2-EGFR Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cellular Component Organization Schwann Cell Development Presynaptic Membrane Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Cell Growth Positive Regulation Of Cell Communication Protein Kinase Activity Positive Regulation Of Signaling Receptor-mediated Endocytosis Ephrin Receptor Binding Positive Regulation Of ERK1 And ERK2 Cascade Clathrin-dependent Endocytosis Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAP Kinase Activity Protein-macromolecule Adaptor Activity Kinase Activity Synaptic Vesicle Endocytosis Positive Regulation Of Protein Phosphorylation Presynaptic Endocytosis Positive Regulation Of Growth Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus
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