RUFY1 and DYNC1LI1

Number of citations: 72 (PubMedID 36282215)
Data Source: BioGRID (affinity chromatography technology, pull down)

		RUFY1	DYNC1LI1
Name		RUN and FYVE domain containing 1	dynein cytoplasmic 1 light intermediate chain 1
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Dynein Complex Endocytic Vesicle Membrane Secretory Granule Membrane Recycling Endosome Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Protein-macromolecule Adaptor Activity Dynein Heavy Chain Binding Molecular Adaptor Activity
	Biological Process	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Synthesis of PIPs at the plasma membrane	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
GWAS		Daytime sleep phenotypes ( 27126917 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Eating disorders ( 22911880 ) Lung cancer ( 28604730 ) Monocyte percentage of white cells ( 32888494 ) TPE interval (resting) ( 32386560 )	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Low density lipoprotein cholesterol levels ( 33339817 )
Novel Interactors		None recorded	6 novel interactors: CMTM6 CMTM7 FBXL2 GPD1L SUSD5 TRIM71
Interacting Genes		20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25	11 interacting genes: BRCA2 CEBPA IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL RUFY1 SLC25A21-AS1
Entrez ID		80230	51143
HPRD ID		15282	10917
Ensembl ID		ENSG00000176783	ENSG00000144635
Uniprot IDs		A8K7B1 Q96T51	B3KM42 E9PHI6 Q9Y6G9
PDB IDs		2YQM 2YW8	6B9H 6PSD 6PSE
GO Terms Enriched among Interactors		Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement	None